Vacation rentals in Mesopotamia

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Top-rated vacation rentals in Mesopotamia

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Guest favorite

A spacious living area features a comfortable sectional sofa, a dining space, and a well-equipped kitchen. Large floor-to-ceiling windows provide expansive views of the surrounding greenery. Natural light floods the space, creating a welcoming atmosphere for relaxation and gatherings.

Home in Peñol

4.91 out of 5 average rating, 127 reviews

Enjoy Nature, Relax & Reset at Casa Chevere!

Casa Chévere is the ideal getaway for friends and family to relax & reset! Wake up to stunning views of Lake Guatapé, surrounded by lush greenery and birds chirping while you enjoy fresh breakfast arepas! Highlights include: - 8-person hot tub - FAST Starlink WiFi - Full kitchen, BBQ, fire pit - 15 mins to La Piedra - 25-min to Guatape Please Note: Unfortunately due to the ongoing drought in Colombia, the lake has receded from the house, so the use of the kayaks is not possible at the moment.

Top guest favorite

The modern cabin is nestled among greenery, featuring a deck that extends outdoors. Large glass doors allow views of the lush surroundings. The exterior showcases a mix of stone and wood accents, creating a harmonious blend with nature.

Tiny home in Guatape

4.98 out of 5 average rating, 508 reviews

Foresta: Modern cabin with views of the rock

FORESTA is a modern cabin created with love for you to have an unforgettable stay in the middle of nature, with total comfort. Enjoy the privileged views from the deck, chill out in the jacuzzi, watch the dozens of birds that visit us or have a chat by the fireplace in the living room. FORESTA is a great launchpad to explore Guatape, climb the rock and do kayaking, jet-ski, wakeboard, sailing, paraglading, horseback riding, hiking, getting a helicopter ride or having an ATV tour. You choose!

Top guest favorite

Two horses are seen standing calmly along a gravel path, surrounded by lush greenery and vibrant flowers. Tall tropical plants provide a natural backdrop, while a scenic farmhouse can be glimpsed in the distance, adding to the serene rural atmosphere.

Villa in Rionegro

4.97 out of 5 average rating, 134 reviews

Sweet Helen Llanogarden

Sweet Helen Llanogarden situado en el Tablazo-Llanogrande, a tan solo 10 minutos del aeropuerto internacional José Maria Córdova de Rionegro Antioquia, cerca a restaurantes, centros de eventos y malls, en el cual ofrecemos servicios de alojamiento para familias, amigos, parejas y viajes de negocios. En Sweet Helen Llanogarden encontrarás el espacio para pasar una estancia segura, tranquila y divertida, esta vez, rodeada de naturaleza y confort en la zona más exclusiva del oriente antioqueño.

Top guest favorite

A spacious living area features large glass walls, offering panoramic views of the surrounding landscape. A comfortable gray sofa is positioned to enjoy the outdoor scenery, while a wooden coffee table sits in front. A jacuzzi is visible outside, surrounded by well-maintained green areas.

Cabin in La Ceja

4.98 out of 5 average rating, 129 reviews

Chalet Los Alpes

Chalet Los Alpes. We are located in La Ceja via La Unión with one of the most spectacular views in the region. With home automation system. You can enjoy green areas, a Jacuzzi, a built-in fire pit, a cinema, a VIP office, two living rooms, a kitchen, 2 bedrooms with private bathroom, 2 closets, fiber optic connection, WiFi area throughout the villa, laundry area, reading area, mobile connectivity, ample parking for 4 cars. Be amazed and visit Chalet Los Alpes, because “Life begins here”.

Guest favorite

An outdoor terrace area features a bar with two high stools. The open space leads into a bright living area, combining modern design with natural elements. A view of the kitchen is visible, alongside a decorative cactus planted in a wall bed.

Condo in El Carmen de Viboral

4.92 out of 5 average rating, 211 reviews

Modern and Comfortable Apartment-El Carmen de Viboral

Beautiful and cozy apartment in the center of Carmen de Viboral with 1 well-equipped master bedroom, a spacious and bright living room with sofa bed, access to terrace, fully equipped kitchen, bathroom and jacuzzi. This apartment has a beautiful view of the town and excellent areas to share as a couple or as a family. It is located 1 minute from the main park, close to pharmacies, ATMs, supermarkets, restaurants and others. This is the preferred place to rest and relax.

Top guest favorite

A sleek kitchen countertop is showcased, featuring a coffee maker, a set of decorative containers labeled 'coffee,' and a stove with cooking utensils. Natural light filters in through large windows, highlighting the texture of the granite surface.

Cabin in La Unión

5 out of 5 average rating, 59 reviews

Wooden Mountain Cabin with lounge net, fast wifi

Enjoy a discount when you book more than one night! Relax in our wooden mountain cabin with stunning Andean views with total privacy for nature lovers. Equipped with a kitchen, fridge, water filter, hot shower, comfy bed, a working place with high speed internet and longe net for daytime relaxation and stargazing at night. The deck offers a perfect spot to enjoy the breeze and birdwatch. Explore nearby attractions like the Salto Del Buey waterfall and short hikes.

Top guest favorite

A portable speaker is positioned on a black surface, accompanied by a microphone. A remote control is present beside the speaker, which features a black casing and a mesh grille. The background shows a glimpse of a cozy sleeping area with warm tones.

Cottage in Medellín

4.97 out of 5 average rating, 238 reviews

PARAISO, MOUNTAIN NATURAL RESERVE

EL RETIRO municipality, 18 Kmts from Medellín Close to LOS SALADOS ECOLOGICAL PARK, LA FE dam with some water sports. BEAUTIFUL VIEW! You'll love my place because it's cozy, high ceilings, nice, warm, quiet, clean, modern, with the best views of Eastern Antioquia. Tourist sites, La Piedra del Peñol, the city of Medellín with its charms. My accommodation is good for couples, adventurers, business travelers, families (with children), large groups, and pets.

Top guest favorite

A bright living area features large glass doors that open to a wooden deck, surrounded by lush greenery. Soft curtains frame the view, and a cozy sofa is positioned nearby. A modern light fixture adds a stylish touch to the inviting space.

Cabin in Retiro

5 out of 5 average rating, 25 reviews

Camino del Ciprés Boutique Cabin

Camino del Ciprés is a completely private boutique cabin located in a nature reserve in El Retiro, Antioquia. Surrounded by the tranquility of a pine forest, rivers and birdsong. Ideal for rest and connection with nature that you can enjoy with family or friends. Enjoy a warm and cool environment, perfect for contemplating the forest or going hiking. We have hot water, a Jacuzzi, catamaran net, fireplace, kitchen, WiFi, TV, and a terrace for barbecues.

Guest favorite

A landscaped garden is showcased, featuring a pathway lined with stones that leads through vibrant greenery and flowering plants. In the background, a pool is visible, surrounded by trees and a wooden structure, all under a clear blue sky with fluffy clouds.

Home in La Ceja

4.93 out of 5 average rating, 42 reviews

Country house, excellent location, beautiful view!

We invite you to enjoy a beautiful space surrounded by nature, with all the comforts so you can relax and rest. You will feel like you are right at home. Ideal place for telecommuting (digital nomads) and long stays. Just 10 minutes from La Ceja, 45 minutes from the international airport and about 1 hour from Medellin. Pets are welcome. Additionally we offer Yoga classes and Ayurvedic therapies (Abhyanga/Swedana). Perfect place for "slow" tourism!

Guest favorite

The cabin is surrounded by a landscaped path and greenery, providing a serene setting. The yellow and green exterior blends with nature, while a porch and a solitary chair invite relaxation. Nearby trees and shrubs enhance the tranquil atmosphere of the property.

Farm stay in Rionegro

4.95 out of 5 average rating, 255 reviews

Retiro Cabin – Woodman's House

Retiro Cabin – Casa del Leñador – fue la primera casa de nuestros sueños: pequeña, acogedora y rodeada de naturaleza. El lugar perfecto para pasar unos días en pareja, un fin de semana en familia o trabajar remoto en un entorno sin distracciones. Despierta con el canto de los pájaros al amanecer y disfruta de una fogata en el deck al atardecer. En Retiro Cabin tendrás total independencia y una vista sin igual del campo en el oriente antioqueño.

Guest favorite

Home in Rionegro

4.94 out of 5 average rating, 176 reviews

A warm house with a Jacuzzi, 5 minutes from JMC airport

Welcome to our cozy loft house just 5 minutes from JMC Airport, it is perfect for a relaxing getaway close to everything. Space for 4 people, offers all the amenities you need for a comfortable stay, it is complete/equipped with all the kitchen implements so you can prepare your favorite meals. In addition, it has a parking lot, WiFi, jacuzzi , deck and catamaran mesh for a unique experience, smart TV. NO parties or loud music

Top guest favorite

Farm stay in Retiro

4.98 out of 5 average rating, 107 reviews

Country Retreat at Finca Sietecueros.

Finca Sietecueros - Natural Refuge and Comfort in One Place Escape to Finca Sietecueros, a country house surrounded by forests and mountains. Relax in the jacuzzi, enjoy the hammocks under the trees, or share stories in the campfire area under a starry sky. Ideal for couples, families, and friends seeking peace, nature, and comfort in a unique setting. Book your stay and live an unforgettable experience in contact with nature!

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Popular amenities for Mesopotamia vacation rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Other great vacation rentals in Mesopotamia

Top guest favorite

Cottage in Rionegro

4.96 out of 5 average rating, 28 reviews

Llanogrande Rionegro Farm House

AdrianaRating, 5 stars5 days ago

Excellent! The family really enjoyed their stay at this beautiful estate. Very comfortable and with many different spaces to enjoy. Excellent and prompt communication with Andrés. Everyone wants to go back to it for our next annual meeting. Excellent location. Very close to supermarkets, restaurants, etc. Thank you very much Andrés!

Guest favorite

Home in Rionegro

5 out of 5 average rating, 31 reviews

Casa Mantra

RobertRating, 5 stars3 weeks ago

If you are interested in visiting this area, this is likely the most beautiful house around! From the landscape, to the incredible detail of the decorations and you don’t need a car to go anywhere. You can hear the river from the many terraces, and the public, paved trail is just behind the property. Highly recommend this location and the service from start to finish was impeccable.

Top guest favorite

A wooden cabin is positioned on a grassy hillside, with a sunset backdrop illuminating the sky in warm hues. Surrounding trees frame the cabin, enhancing its natural setting. The mountains are faintly visible in the distance under a soft, cloudy sky.

Place to stay in Montebello

4.95 out of 5 average rating, 65 reviews

horse mountain, nature surrounded by nature

TatianaRating, 5 stars3 weeks ago

This place is peaceful and beautiful. They keep it super tidy and the surroundings are well maintained. Alejandro is very attentive and ready to help. The place has everything you need in a small space. Loved it!

Superhost

A modern home is presented with a concrete facade and expansive glass walls. A serene outdoor space includes a patio with dining chairs and a barbecue area, alongside a small pool. Lush greenery surrounds the property, enhancing the tranquil setting.

Home in Rionegro

5 out of 5 average rating, 3 reviews

Malbec Luxury Villa in the Woods - villa 2

RohanRating, 5 stars2 weeks ago

It was really great place. We enjoyed. Ari helped us a lot thank you very much.

Top guest favorite

Wooden shutters frame a view of lush greenery and distant mountains. The vibrant landscape is bathed in natural light, highlighting the intricate textures of the trees and the prominent Piedra El Tabor in the background.

Tiny home in San Carlos

5 out of 5 average rating, 29 reviews

Unique style guadua cabin in San Carlos-Ant

JhanaRating, 5 stars2 weeks ago

Santiago is an incredible host. He helped us find local activities and communicate with local guides. The place is absolutely beautiful. The hike up there is no joke. But if you’re willing to put in the effort, it’s absolutely worth it.

Guest favorite

A shaded outdoor seating area is presented with two comfortable chairs and a large wooden coffee table featuring decorative items. Lush greenery and mountains can be seen in the background, creating a serene view of the surrounding landscape.

Farm stay in La Pintada

4.91 out of 5 average rating, 32 reviews

Farm in La Pintada, Antioquia

YelenisRating, 5 stars1 month ago

We loved the farm, it's beautiful, you can enjoy nature and comfort. Alejandra is very attentive to details and answers any questions. Mrs. Estela cooks delicious and Mr. Pacho is also very helpful. 10 out of 10🥳.

A large window frames a stunning view of lush greenery and blue skies. A peaceful dog rests outside, enjoying the landscape. The interior features a potted plant, adding a touch of life to the space, while natural stone flooring enhances the connection with nature.

Place to stay in Mesopotamia

4.73 out of 5 average rating, 11 reviews

Villa Paraíso Natural: Peace, River, and Waterfalls

RobertoRating, 5 stars5 months ago

The first thing is to thank the hosts, they are a spectacular family with a huge energy, which at the entrance makes the visit more pleasant; from Bogotá the road is very good, poorly lit in case they plan to travel at night, the directions to get to the house are very clear, the last section if the car is low to have a little patience, it is a road uncovered but worth it; regarding the house it is the same as the photos, a place too quiet, ideal to get out of the hut and noise of the city and connect in a natural environment, it is a temperate climate but in the evenings you can lower the temperature I recommend carrying a bag; it would be a place where I would return with my family.

Top guest favorite