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Vacation rentals in Mesopotamia

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Mesopotamia

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
Cabin in Rionegro
4.87 out of 5 average rating, 106 reviews

The Ultimate Group House w/ Hot Tub & Amazing View

About this space 🌟 2 bedrooms, each with a double bed & private bathroom 🛏️ Double sofa bed in the living room 🛋️ Bathrooms with hot water & fresh towels 🚿 Living room with Smart TV & WiFi 📺 Private jacuzzi for relaxation 💦 Fully equipped kitchen 👩‍🍳 Ninja Foodi electric grill for cookouts 🍖 Catamaran net, dining table & spacious deck/terrace 🌞 Private parking space 🅿️ Portable heater available 🔥 Breakfast can be ordered via Rappi (delivery app). We can assist with your order 🍳

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Top guest favorite
Tiny home in Cocorná
5.0 out of 5 average rating, 71 reviews

lovely cabin with sauna, jacuzzi and private river

Enjoy the beautiful nature and tranquility of this luxurious accommodation with a sauna, jacuzzi, and private river terrace. Just 75 minutes from Medellín, this beautiful cabin is easily accessible by any car or motorcycle. The spectacular surroundings of Cocorná have much to offer, including paragliding, rafting, quad biking, and hiking trails along beautiful rivers. We are happy to assist you with transport or activities. We offer private transport from the airport! Includes breakfast!

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Guest favorite
Cabin in Carmen de Viboral
4.9 out of 5 average rating, 90 reviews

Espi Ritual

Step into tranquility and reconnect with nature in this serene Llano Grando cabin. Soak up the patio sun, immerse yourself in the beautiful garden, or spot countless bird species on the sun-deck overlooking the pond. This cabin is equipped with WiFi, a full kitchen, an asador, and a private entrance. The perfect location for a peaceful solo trip, charming romantic getaway, or unique family adventure. 15 minutes from charming San Antonia and near restaurants and shopping

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Top guest favorite
Cabin in Rionegro
5.0 out of 5 average rating, 52 reviews

Selvva suites | luxury cabin in a forest + jacuzzi

Escape to SELVVA SUITES, a luxury retreat immersed in the tranquility of a native forest, just 50 minutes from Medellín. Located on the Llanogrande–La Ceja road, only 15 minutes from Llanogrande mall and 20 minutes from JMC Airport in Rionegro. Enjoy a King-size bed and a private jacuzzi surrounded by nature. Private parking with easy access for any type of vehicle. ⚠️ ✈️We are in an area with air traffic, and airplane noise can be heard. 🐾 Pet friendly

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Top guest favorite
A modern structure emerges from lush greenery, framed by vibrant plants and a manicured lawn. Large glass doors lead to a spacious deck, offering a view of the mountains and a colorful sky. Pathway stones create a welcoming entrance.
Home in La Ceja
4.95 out of 5 average rating, 61 reviews

Country house, excellent location, beautiful view!

We invite you to enjoy a beautiful space surrounded by nature, with all the comforts you need to relax and unwind. You will feel like you are right at home. Ideal place for teleworking (digital nomads) and long stays. Just 10 minutes from La Ceja, 45 minutes from the international airport, and 1 hour from Medellín. Pets are welcome. Additionally, we offer yoga classes, Ayurvedic therapies (Abhyanga/Swedana), and tennis lessons. Perfect place for "slow" tourism!

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Superhost
A modern cabin with a unique arched design is set against a vibrant sunset sky. The entrance features large glass doors framed by black accents, while the surrounding landscape showcases rolling hills that extend into the distance.
Cabin in La Ceja
4.85 out of 5 average rating, 55 reviews

Casi Cielo! Heaven's Edge

Nestled 7,000 feet high, our tranquil cabin promises breathtaking mountain and waterfall vistas. This retreat, perfect for romantic getaways or family escapades, enchants with its warming fire pit and rejuvenating hot tub. Experience the stunning wilderness, bask in the magnificent scenery, and craft unforgettable memories. This is not just a stay, but an experience enveloped in serene beauty, embracing the extraordinary amidst the ordinary. (500 characters)

LocationGrillSleep quality

Superhost
Villa in Envigado
5.0 out of 5 average rating, 5 reviews

Luxury Lake Mansion: Pool & 15 min to Poblado

Indulge in elegance at this private lakeside estate. Relax in your heated pool, jacuzzi, and private sauna. Sprawling across an 86,000 sq ft lot (750 m2 built) over 3 levels, it features 5 bedrooms, each with a bathtub and walk-in closet. Enjoy grand living areas, a magnificent foyer, and an open-concept layout perfect for entertaining. Take in breathtaking views from the expansive patio—all just 15 min from El Poblado. The epitome of high-end luxury living.

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Guest favorite
Cabin in Retiro
4.98 out of 5 average rating, 60 reviews

Camino del Ciprés Boutique Cabin

Camino del Ciprés is a completely private boutique cabin located in a nature reserve in El Retiro, Antioquia. Surrounded by the tranquility of a pine forest, rivers and birdsong. Ideal for rest and connection with nature that you can enjoy with family or friends. Enjoy a warm and cool environment, perfect for contemplating the forest or going hiking. We have hot water, a Jacuzzi, catamaran net, fireplace, kitchen, WiFi, TV, and a terrace for barbecues.

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Superhost
An outdoor deck area features a hammock hanging beside a small jacuzzi, complemented by a dining table for four. Large sliding doors provide a view into the interior space, where a cozy atmosphere is highlighted by warm lighting and natural wood elements.
Villa in Rionegro
4.94 out of 5 average rating, 193 reviews

Sweet Helen Llanogarden

Sweet Helen Llanogarden is located in Tablazo-Llanogrande, just 10 minutes from José Maria Córdova de Rionegro Antioquia International Airport, close to restaurants, event centers, and malls. We offer accommodation services for families, friends, couples, and business trips. At Sweet Helen Llanogarden you will find the space to spend a safe, quiet and fun stay, this time surrounded by nature and comfort in the most exclusive area of eastern Antioquia.

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Top guest favorite
Farm stay in Cocorná
4.98 out of 5 average rating, 61 reviews

Bali-style cabin with forest and private river

Bali-style cabin with more than 2 hectares of private forest and river, hot Jacuzzi, wifi, spring climate, combining luxury and nature, deck next to the river, campfire, cinema-type video projector, shower with a view of nature, work and reading area, beautiful night lighting, kitchen and BBQ area, sun loungers and many other details designed to give you a unique experience and invite you to slow down and reconnect with yourself and nature

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Superhost
Farm stay in Cocorná 054440,
4.86 out of 5 average rating, 65 reviews

Jamaica House: private river and jacuzzi Cocorná

Beautiful house nestled in the heart of nature, surrounded by over 60 hectares of native forest and pastures. Featuring a hot jacuzzi, exclusive private river access to enjoy in peace, gentle and trail-savvy horses, open-air showers with spectacular mountain views, a cozy wood-burning fire pit for welcoming nights, hammocks, and everything essential to truly disconnect—perfect for friends, family, or couples.

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Guest favorite
Villa in La Ceja
5.0 out of 5 average rating, 13 reviews

Family farm in La Ceja with a beautiful view and fireplace

Enjoy this charming country villa in La Ceja, ideal for families. Surrounded by nature and boasting stunning views, it offers 4 bedrooms plus a utility room, spacious gardens, an equipped kitchen, a fireplace, a double-height living room, and bright social areas. It has a kiosk with a barbecue area. It's the perfect place to relax, spend time with family or friends in a natural, safe and exclusive setting.

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Popular amenities for Mesopotamia vacation rentals