Guesthouse vacation rentals in Knox County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Knox County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

Guesthouse in North Knoxville

Fourth and Chill Flat (w/ EV Charger)

A newly renovated urban guesthouse with historic charm located in beautiful historic Knoxville. This lovely apartment is ideal for 2 people but can accommodate up to 4 who want to enjoy a taste of the city life close to downtown in a safe neighborhood. *Walk to coffee, breweries, acai bowls & restaurants *Be anywhere downtown in 5 minutes or less by car *Highway access less than 2 minutes away *Free Parking *Full Kitchen *Washer/Dryer *Scooter or bike anywhere downtown Knoxville Permit #67654

LocationValueBathroom

4.98 out of 5 average rating, 101 reviews

Guest favorite

Guesthouse in Maryville

Relax in a Smoky Mtn getaway near Knoxville

Welcome to our centrally located residence! Explore Pigeon Forge & Gatlinburg (1hr away), perfect for motorcycle enthusiasts with easy access to Tail of the Dragon and Foothills Parkway. Nearby bike/walking paths, 30min to downtown Knoxville, and 4 miles from the airport. Restaurants, fast food, and shopping within 15 minutes. Please note that ALL outdoor spaces are SHARED with your host. We respect your privacy and won't intrude on your grilling or swimming experience. Smoking is not allowed.

FamilyLocationHeating

4.92 out of 5 average rating, 181 reviews

Top guest favorite

A cozy sleeping area features a spacious bed adorned with a lace coverlet. A comfortable sofa and armchair offer seating under the warm glow of two lamps, while a decorative rug adds texture to the wooden floor. Artwork decorates the walls, enhancing the room's charm.

Guesthouse in Oak Ridge

The "Tree House" - Privacy, Luxury, Nature Views

The elegant "Tree House'' is not in a tree but feels like it - with large windows overlooking lush forest or mountain views. This 450 sf space is a separate unit with own entrance & porch - no stairs! Queen bed, sofa, stone/tile bathroom & walk-in shower, big TV, fast WiFi, birdfeeders, washer-dryer. Located on cozy safe cul-de-sac, reserved parking. Unique architect-designed space has kitchenette with fridge, toaster oven, microwave, Keurig coffee, more. Hiking trails nearby! Non-smoking.

LocationFamilyAir conditioning

4.98 out of 5 average rating, 443 reviews

Top guest favorite

Guesthouse in Knoxville

FablewoodCottage -hot-tub/woodland/storybook decor

An Enchanting escape from ordinary. It has charm and whimsy with a touch of luxury. Located only 4.7 miles from Downtown Knoxville or UT Campus, 38 miles from Pigeon Forge and 2.5 miles from Baker Creek and Knoxville's Urban Wilderness, it is perfect for a girls trip, a romantic getaway or wilderness adventure. The private back deck and therapy spa provide relaxation after a day of hiking, biking or exploring downtown. This fairy-tale inspired cottage is the perfect setting for your next story.

LocationFamilyCondition

5.0 out of 5 average rating, 75 reviews

Top guest favorite

Guesthouse in Knoxville

The Havana Cabana

Welcome to the Havana Cabana! Inspired by the historic architecture tours I lead to Cuba, this 1926 garage has been converted into a fun and cozy guest house just 5 minutes from Downtown and 10 minutes from the University of Tennessee. We are also on a city bus line. The guest house is located in my fenced backyard and offers secure parking and a large outdoor space for relaxing. We require you have at least 2 positive Airbnb reviews to book. No pets please since I have 3 small dogs on site.

LocationValueAccuracy

5.0 out of 5 average rating, 18 reviews

Guest favorite

Guesthouse in Knoxville

Knoxville Comfort: Hot Tub-Grill-Fenced Patio-Pets

Welcome to your private Knoxville retreat! This modern 1-bedroom, 1-bath guesthouse offers a great mix of comfort and relaxation. Unwind on the private patio, soak in the hot tub under the stars, or relax inside with chic decor and cozy vibes. Located in a quiet neighborhood in North Knoxville/Fountain City — just minutes from downtown, UT, and the Smoky Mountains. We love travelers from all walks of life - and their pet friends too! Perfect for: Couples, solo travelers, and business stays

LocationFamilyCheck-in

4.98 out of 5 average rating, 94 reviews

Top guest favorite

A cozy living area features a blue sofa positioned on a light grey rug. A wooden coffee table is adorned with speakers and decor. The space is illuminated by natural light from a nearby window, while a wall-mounted TV and decorative mirrors enhance functionality.

Guesthouse in Knoxville

The Garage Mahal

Kick back and relax in this calm, stylish space. Built in 2022, The Garage Mahal guest house provides easy access to all the West Knox amenities. The space is a fully furnished, apartment-style upstairs guesthouse. The apartment has a coffee maker, mini fridge, and microwave. Its bedroom is set up with a queen-size Nectar mattress and plenty of storage.The living area is comfy with a small sectional and a smart TV with Netflix. There's also a small breakfast table with seating for two.

LocationFamilyQuiet

4.99 out of 5 average rating, 102 reviews

Top guest favorite

A welcoming living area features a sleek futon and a woven chair, arranged on a patterned area rug. Natural light fills the space through sliding glass doors, which lead to an outdoor deck, framed by lush greenery visible outside.

Guesthouse in Powell

Private Guesthouse—serene & conveniently located!

Surrounded by woods, this peaceful studio guesthouse provides a retreat-like setting close to our vibrant downtown. The private quarters feature granite countertops, fully-stocked kitchen, separate entrance, comfy bed, sun-filled rooms & a lovely, outdoor seating area to enjoy the quiet. *4 min to Kroger grocery & restaurants *6 min to Tennova North Hospital—perfect for travel nurses! *12 min to downtown *16 min to UT's Neyland Stadium & Thompson Boling Arena *1 hr to the Smoky Mountains

FamilyLocationCheckout

4.99 out of 5 average rating, 299 reviews

Top guest favorite

Guesthouse in Fountain City

The Burrow • A Fountain City Cottage

Burrowed in the trees just enough to feel secluded, but close to everything Knoxville has to offer, this little gem will feel like home the second you step inside. While you share a driveway with the host, the house is completely separate. Less than 15 minutes from UT campus, Thompson Boling Arena, and Neyland Stadium. Less than 30 miles to Pigeon Forge and just a little farther to Gatlinburg and the Smokies. 5 minutes to groceries, restaurants and coffee 10 minutes or less to shopping

FamilyLocationOutdoor spaces

4.99 out of 5 average rating, 90 reviews

Top guest favorite

A charming modern log house is nestled among trees, featuring a metal roof and a welcoming porch. Surrounding greenery and landscaped flower beds enhance the natural setting, providing a serene entrance to the home.

Guesthouse in Maryville

Little River Cabin in the Woods

Upon your arrival to this secluded setting, you will find a charming modern log house. No detail has been overlooked in the decor and furnishings to make you feel at home. On the main floor is a generous living area which includes a contemporary kitchen with many amenities, a bathroom with a walk-in shower and a laundry room, if needed. Up the staircase is the loft with a king size bed, a twin XL daybed and a sleeper sofa. Pls note: this property is unsuitable for children 12.

ValueLocationCheck-in

4.98 out of 5 average rating, 233 reviews

Top guest favorite

A cozy sleeping area features a spacious bed with white linens and several pillows, arranged against warm wooden paneling. Soft wall sconces provide gentle illumination. A decorative mirror is positioned above the bed, reflecting light from a nearby window.

Guesthouse in Fountain City

Private North Knox Guesthouse - close to downtown

In the middle of beautiful trees, this peaceful studio guesthouse provides a refreshing setting very close to downtown. The private quarters feature fresh white linens, fully-stocked kitchen, separate entrance, comfy bed, sun-filled rooms & a lovely, outdoor seating area. *4 min to Kroger grocery & restaurants *11 min to Tennova North Hospital, perfect for travel nurses! *12 min to downtown *13 min to UT's Neyland Stadium & Thompson Boling Arena *50 min to the Smoky Mountains

LocationValueAir conditioning

4.96 out of 5 average rating, 315 reviews

Guest favorite

A circular wooden sign features the name 'Knoxville' prominently, accompanied by stylized mountains and waves. Surrounding details include leaves and branches, enhancing the natural theme of the piece.

Guesthouse in North Knoxville

Minimalist Efficiency - 4.2 miles from Downtown

It is perfect for mid-term and long-term stays for couples traveling with one child, college students, remote workers, and more. Efficiency size about 150 sqft Wifi and Ethernet Connection 3.8 - 5.2 Miles / 8-12 Minutes to Downtown (Depends on Traffic) 3-5 Minutes to Grocery store 3-5 Minutes to Restaurants and Fast food 15 Minutes to Hikes/Attractions 20 Minutes to the Airport 31- 34 Miles / 45 Minutes to Pigeon Forge 39 - 42 Miles / 50 Minutes to Gatlinburg

ValueFamilyAccuracy

4.92 out of 5 average rating, 290 reviews