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Hotels in Jackson County

Find and book unique hotels on Airbnb

Top-rated hotels in Jackson County

Guests agree: these hotels are highly rated for location, cleanliness, and more.

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Top guest favorite

Hotel room in Murphysboro

4.94 out of 5 average rating, 71 reviews

Huge Tower Suite With King Bed & Private Bath

Included: 1. (2) 20 minute red light sauna therapy sessions 2. Self serve coffee and snack bar Sleep like Royalty in a turret! The bed is a King size Lucid memory foam mattress. It is so comfortable! There is a a table for two, a loveseat, fireplace, closet with hangers, extra blankets and pillows, easy step in shower, and beautiful views out of the 11 windows! The room is so spacious at about 300 square feet. It’s is so bright a cheery! You will love it!

The Labrador Lakehouse is a multi-level structure surrounded by open green space. A spacious veranda wraps around the building, offering ample outdoor seating. A brown dog can be seen in the foreground, contributing to the welcoming ambiance of the property.

Hotel room in Murphysboro

4.96 out of 5 average rating, 49 reviews

Tower En-suite King Bed & Bath Lake Views

Included: 1. (2) 20 minute red light sauna therapy sessions 2. Self serve coffee and snack bar Sleep well in this comfy King size bed in a tower with 4 wrap around windows. You will have extra blankets and pillows if you need them. Your private bathroom has a shower tub combo. You can adjust your own thermostat to get your perfect temperature. We have 4 en-suite bedrooms available for reservations and each room can be booked separately.

Hotel room in Carbondale

New place to stay

Carbondale Main St. Suite

Grand Opening: University Inn of Carbondale – The Premier SIU & Shawnee Base Welcome to Carbondale's newest, most convenient stay! Located right on West Main Street, the University Inn is your perfectly situated home base, whether your trip centers on academics, athletics, or outdoor adventure. We have crafted a clean, comfortable, and well-equipped space to ensure a relaxing stay for every guest.

A multi-level house is set beside a serene lake, reflecting its green and white exterior. The property features a spacious deck that overlooks the water, providing a peaceful environment surrounded by nature.

Hotel room in Murphysboro

5 out of 5 average rating, 51 reviews

King Bed Suite with Private Bathroom

Included: 1. (2) 20 minute red light sauna therapy sessions 2. Self serve coffee and snack bar Put your feet up and stay for a while! This executive suite has a King bed, futon couch, coffee table, closet, two dressers, and a private bathroom. You will have extra pillows and blankets, and your own thermostat to adjust. This room is spacious and comfortable for up to three guests.

Hotel room in Carbondale

New place to stay

Walk to Saluki Stadium! Nov 15 Football Weekend

Saluki Stadium and SIU are just steps away! Enjoy ample parking, fast Wi-Fi, a spacious living area, and a tailgate-ready kitchen. Relax in the private backyard, explore favorite Carbondale spots, and relive campus memories. Perfect for alumni and football fans—your home for game day comfort and local experiences.

The building features a modern façade illuminated by soft lighting. Tall columns support the covered entrance, while large glass windows provide a view into the interior. Landscaping includes neatly arranged shrubs, enhancing the inviting appeal of the entryway.

Hotel room in Carbondale

Cozy & Quiet Stay

You’ll be charmed by this adorable place to stay.

A well-lit guestroom features two spacious beds with crisp white linens. A desk and chair are positioned nearby, and a mounted flat-screen television is visible on the wall. The doorway in the background leads to the hallway, providing easy access.

Hotel room in Carbondale

Comfortable Stay

You’ll be charmed by this adorable place to stay.

A welcoming entrance is featured with tall white columns supporting a large overhang. Bright lighting illuminates the facade, highlighting the brick exterior. Decorative landscaping frames the walkway, enhancing the inviting appearance of the entryway.

Hotel room in Carbondale

Little Luxuries - Big Comfort

You’ll be charmed by this adorable place to stay.

An exterior view of a welcoming building is illuminated at night by soft lighting. The entrance features tall columns and large glass doors, inviting guests inside. Neatly landscaped areas with low shrubs surround the entrance, enhancing the overall outdoor ambiance.

Hotel room in Carbondale

Easy Access - Budget Friendly

You’ll be charmed by this adorable place to stay.

A well-lit room features two spacious beds with white linens and dark headboards. A television is mounted on the wall opposite the beds. A desk with a chair is positioned nearby, while a door leads to the hallway in the background.

Hotel room in Carbondale

Luxurious Stay

You’ll be charmed by this adorable place to stay.

The exterior of a well-lit building is showcased, featuring a covered entrance supported by tall columns. Soft orange lighting highlights the architecture, while large glass panels offer a view into the lobby area, where a chandelier can be partially seen.

Hotel room in Carbondale

Explore Carbondale in Comfort

You’ll be charmed by this adorable place to stay.

A well-lit guest room features two spacious beds with white bedding and neutral-toned headboards. A bedside lamp provides additional lighting, while a flat-screen TV is mounted on the wall. A desk is positioned in the corner, contributing to a functional layout.

Hotel room in Carbondale

Rest Easy, Sleep Happy

You’ll be charmed by this adorable place to stay.

Popular amenities for Jackson County hotels

Free parking on premises

Air conditioning

Family-friendly hotels

The building features a modern façade illuminated by soft lighting. Tall columns support the covered entrance, while large glass windows provide a view into the interior. Landscaping includes neatly arranged shrubs, enhancing the inviting appeal of the entryway.

Hotel room in Carbondale

Cozy & Quiet Stay

A multi-level house is set beside a serene lake, reflecting its green and white exterior. The property features a spacious deck that overlooks the water, providing a peaceful environment surrounded by nature.

Hotel room in Murphysboro

5 out of 5 average rating, 51 reviews

King Bed Suite with Private Bathroom

A well-lit guestroom features two spacious beds with crisp white linens. A desk and chair are positioned nearby, and a mounted flat-screen television is visible on the wall. The doorway in the background leads to the hallway, providing easy access.

Hotel room in Carbondale

Comfortable Stay

A welcoming entrance is featured with tall white columns supporting a large overhang. Bright lighting illuminates the facade, highlighting the brick exterior. Decorative landscaping frames the walkway, enhancing the inviting appearance of the entryway.

Hotel room in Carbondale

Little Luxuries - Big Comfort

Hotel room in Carbondale

New place to stay

Walk to Saluki Stadium! Nov 15 Football Weekend

An exterior view of a welcoming building is illuminated at night by soft lighting. The entrance features tall columns and large glass doors, inviting guests inside. Neatly landscaped areas with low shrubs surround the entrance, enhancing the overall outdoor ambiance.

Hotel room in Carbondale

Easy Access - Budget Friendly

The exterior of a well-lit building is showcased, featuring a covered entrance supported by tall columns. Soft orange lighting highlights the architecture, while large glass panels offer a view into the lobby area, where a chandelier can be partially seen.

Hotel room in Carbondale

Explore Carbondale in Comfort

Top guest favorite

Hotel room in Murphysboro

4.94 out of 5 average rating, 71 reviews

Huge Tower Suite With King Bed & Private Bath

Hotels with a pool

Hotel room in Jackson

New place to stay

1BD at The Branson Meadows

Hotel room in Jackson

New place to stay

2BD at The Branson Meadows

The reception desk features a clean, neutral countertop, equipped with a computer and a vertical monitor. A visitor stands in front of the desk, interacting with the staff member who is positioned behind it. A plant is placed on the counter, adding a touch of greenery.

Hotel room in Vienna

4 out of 5 average rating, 8 reviews

King Size Jacuzzi Room Vienna

Hotel room in Jackson

New place to stay

4BD at The Branson Meadows

Hotel room in Jackson

New place to stay

3BD at The Branson Meadows

Hotels with a patio

The exterior of a historic building is showcased, featuring a white façade with decorative architectural details. A corner entrance is highlighted by columns, and outdoor seating with umbrellas is visible. Scenic trees and streetlights can also be seen, contributing to the appealing streetscape.

Hotel room in Ste. Genevieve

4.67 out of 5 average rating, 3 reviews

The Audubon - Partridge Rm 4

A cozy sleeping area features a spacious bed adorned with white bedding and blue accent pillows. Decorative wall art is mounted above the bed. A lamp and a small table sit beside the bed, while a kitchenette area with a microwave is visible in the background.

Hotel room in Ste. Genevieve

Our Little Gemm at The Inn

A well-appointed bedroom features a large bed with a white comforter. A decorative wall showcases leafy patterns. Natural light is filtered through light-colored window shades. Additional furnishings include a wooden table, two rattan chairs, and an accent lamp, creating a serene and inviting environment.

Hotel room in Cape Girardeau

5 out of 5 average rating, 3 reviews

The Palms at Rockwood Inn

A spacious room features two queen beds with decorative throws placed at the foot. The polished wood flooring complements the warm tones of the bedding. A cozy seating area is visible, alongside a desk and a comfortable chair, under natural light from nearby windows.

Hotel room in Cape Girardeau

The Vista at Rockwood Inn

A spacious bedroom features a Queen-sized bed with a dark headboard, complemented by a plush green throw blanket. Decorative wallpaper adds a classic touch, while a wooden desk and chair provide a workspace. Light enters through a window dressed with blackout shades, enhancing comfort.

Hotel room in Cape Girardeau

4.75 out of 5 average rating, 4 reviews

The Grove at Rockwood Inn

Top guest favorite

A spacious bedroom features a king bed with dark bedding and coordinating pillows. A pull-out loveseat is positioned at the foot of the bed. Large windows with plantation shutters provide natural light, while a crystal chandelier adds elegance to the coffered ceiling.

Hotel room in Red Bud

4.98 out of 5 average rating, 65 reviews

Charming suite with King Bed

A well-appointed bedroom features a spacious queen bed with crisp white linens. A modern writing desk is positioned beside a stylish lamp, and a plush area rug provides texture. The room is complemented by large windows with roller shades, and a contemporary chandelier adds an elegant touch.

Hotel room in Cape Girardeau

The Cosmopolitan at Rockwood Inn

An exterior view of Hotel Audubon shows a welcoming entrance with large windows displaying the hotel name. The inviting porch features a small table and chairs, while nearby greenery enhances the structured façade. Warm indoor light illuminates the space, highlighting the entrance stairs.

Hotel room in Ste. Genevieve

The Audubon - Lincoln Finch Rm 1