
Vacation rentals in Isla Drake
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Top-rated vacation rentals in Isla Drake
Guests agree: these stays are highly rated for location, cleanliness, and more.

Puntita Manzanillo, fantastic sea and jungle
Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.
4.97 out of 5 average rating, 115 reviews
CARA AL MAR Cacique (Parque de Portobello)
Une maison ! véritable îlot de verre au cœur de la jungle ! Au beau milieu du Parque National de Portobello (accès uniquement en 4x4 AWD) blotti au sommet de la colline, entre ciel/mer, à l'abri de tout regard, une maison transparente où le verre épouse la nature de tous côtés créant une connexion unique entre l'intérieur et l'extérieur, ideal pour se reposer, se déconnecter, confortable, spacieuse, fraîche (clim centrale), exclusive. Elle est le témoin d'un spectacle grandiose qui vous attend !
4.98 out of 5 average rating, 58 reviews
BeachfrontHouse+Kitchen+Balcony+AC+WiFi@IslaGrande
✔️SuperAnfitrión Verificado ¡Tu estadía estará en las mejores manos! 🚨Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones especiales 📍 Apartamento en Isla Grande, Provincia de Colon, Panamá 🇵🇦 🏡 Espacio limpio, cómodo y seguro, con excelente ubicación 🧼 Dotado con insumos y productos de limpieza Durante tu reserva, tu Airbnb cuenta con: 🌐Wifi 📺TV 🍳Cocina 🌊Frente al mar ❄️A/C 🚗Parqueo 👉Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones
5.0 out of 5 average rating, 4 reviews
Dreamy, Modern Caribbean Home at Playa Escondida
Have fun with the whole family at Casa Capri, a dreamy place which is a perfect fit both for adults & kids. The apartment is at Playa Escondida, a stylish resort with white sand beaches and crystal clear ocean water, several amenities such as a restaurant (with a broad range of great food, including fresh seafood and sushi!), pools to chill or swim, plus fantastic and diverse children playgrounds. Whether you'd like to have a resting vacation or a fun getaway, Casa Capri got you covered. Enjoy!
4.86 out of 5 average rating, 103 reviews
The Bird's Nest in the Clouds
Escape to the Clouds: A Nature Lover’s Retreat. Welcome to The Bird's Nest, a serene loft in Santa Rita Arriba, Colón, 50 minutes from the city. Perched in the mountains, this open-concept space offers breathtaking views, fresh breezes, and the sounds of nature - rain and birds. Sleep with doors open, no AC. Perfect for nature lovers, not for those needing silence or climate control. Pool with breathtaking view, wifi and modern comforts included. PLEASE READ ENTIRE DESCRIPTION BEFORE BOOKING.
4.95 out of 5 average rating, 20 reviews
Beachfront House in Caribbean sandy beach
Enjoy this rustic and cozy cottage with its almost private beach surrounded by beautiful palm trees along the whole area. With 2 oceanview bedrooms, 2 full bathrooms and a third bedroom in a mezzanine. Has a patio with a built in uruguayan parrilla, ideal for BBQs. Step in beautiful white sand and bath in crystal clear water. Coconut breakfasts watching the sunrise become a routine in this paradise. - This is a rural setting. Not a 5 star hotel. Insects and small animals can be around.
4.88 out of 5 average rating, 96 reviews
Beachfront Home | En-Suites + Chef & Tours Avail
Wake up to the sound of the waves… More than a beachfront home, Zola Sol is a curated wellness and lifestyle experience, thoughtfully designed around you. Whether you’re looking to relax, reconnect, or celebrate, we can personalize your stay with experiences such as private chef, wellness services, juice offerings, boat tours, and more—all seamlessly arranged before or during your visit. Your Airbnb reservation is simply the first step in creating an unforgettable Zola Sol experience.
4.73 out of 5 average rating, 11 reviews
Beachfront · Large Sea View · Family Friendly
Welcome to Kasa Leilani, a charming beach house nestled between the jungle and the reef in the heart of a natural park. With stunning views of the nearby Caribbean islands, this peaceful retreat offers the perfect blend of nature and comfort. Surrounded by abundant wildlife, you can relax, explore the reef, or discover the island and crystal-clear waters. Kasa Leilani provides a serene escape for nature lovers and beach enthusiasts alike, offering an unforgettable tropical getaway.
4.94 out of 5 average rating, 99 reviews
Entire Villa with pool in front of beach!
Beautiful spacious 4 bedroom villa right in front of the sea. Enjoy the swimming pool with your family, then take a dip into the sea only steps away. Very pet friendly! Take a boat trip for the day with a local certified tour guide from portobelo town. Every room has full AC, including the living room - but please be conscious of the environment when using ACs. Excellent WiFi ! Open Kitchen, with breakfast included. We can also arrange for lunch - fresh lobster!
4.97 out of 5 average rating, 88 reviews
Playa Escondida with the Best Direct Ocean View
Wake up to the Caribbean blue from your private balcony, coffee in hand. Enjoy direct beach access, breathtaking ocean views, and a peaceful escape just one hour from the city. 4 rooms & 4 bathrooms ⭐ Premium - Fully stocked kitchen - In-unit washer and dryer - Nespresso/Drip/French Press coffee machine - High-speed WiFi - Ergonomic desk and office chair - Baby crib - High chair (baby)
4.99 out of 5 average rating, 95 reviews
Oceanfront House in Portobelo | SkyBluebyGuanche
Escape to an oceanfront paradise in Portobelo Leave daily stress behind at SkyBluebyGuanche, a cozy home surrounded by tranquility, lush greenery, and the soothing sound of the ocean. Situated on the beautiful coast of Portobelo, this property is the ideal retreat for families, couples, or groups of friends looking to unwind, enjoy the sea breeze, and take in unforgettable sunsets.
4.81 out of 5 average rating, 94 reviews
“Hermosa y Cómoda Villa en Playa Escondida Resort”
Luxury Resorts y Villa, front lagoon view y playa solamente a 2min, Disfruta de una estadía cómoda y tranquila en este alojamiento totalmente equipado, ideal para matrimonios, familias, grupos pequeños o viajeros de negocios. Tiene capacidad para hasta 6 huéspedes, ofreciendo un ambiente acogedor, limpio y funcional,una terraza amplia,sin duda para una estancia agradable,
4.97 out of 5 average rating, 65 reviewsPopular amenities for Isla Drake vacation rentals
Other great vacation rentals in Isla Drake

Mountain Retreat
4.97 out of 5 average rating, 93 reviews
Casa Condal - Your Luxury Retreat in Cerro Azul
5.0 out of 5 average rating, 28 reviews
Luxury Beachfront Escape | Playa Escondida Resort
5.0 out of 5 average rating, 19 reviews
3 bedrooms with direct access to the sea
4.87 out of 5 average rating, 23 reviews
•Escápate al paraíso con vista al mar•
5.0 out of 5 average rating, 37 reviews
La casa de la guaira (Frente al mar)
4.79 out of 5 average rating, 114 reviews
AeolusGuestHouse Home in Portobelo National Park
5.0 out of 5 average rating, 15 reviews
Amanecer Caribe at Playa Escondida Resort & Marina
5.0 out of 5 average rating, 92 reviews




