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Vacation rentals in Isla Drake

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Isla Drake

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
Two rustic-style cabins are set along the shoreline, surrounded by lush tropical trees. A wide patio is furnished with colorful chairs, offering views of the water. The natural beauty of the landscape is complemented by the tranquil waves gently lapping at the shore.
Home in La Guaira

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

4.97 out of 5 average rating, 115 reviews
Top guest favorite
An inviting infinity pool overlooks a stunning coastal view. A spacious seating area, featuring colorful cushions, complements the serene atmosphere. Natural light fills the space, enhancing the connection to the outdoors, while the blue waters of the pool blend seamlessly with the distant ocean.
Villa in Cacique

CARA AL MAR Cacique (Parque de Portobello)

Une maison ! véritable îlot de verre au cœur de la jungle ! Au beau milieu du Parque National de Portobello (accès uniquement en 4x4 AWD) blotti au sommet de la colline, entre ciel/mer, à l'abri de tout regard, une maison transparente où le verre épouse la nature de tous côtés créant une connexion unique entre l'intérieur et l'extérieur, ideal pour se reposer, se déconnecter, confortable, spacieuse, fraîche (clim centrale), exclusive. Elle est le témoin d'un spectacle grandiose qui vous attend !

4.98 out of 5 average rating, 58 reviews
Superhost
Home in Isla Grande

BeachfrontHouse+Kitchen+Balcony+AC+WiFi@IslaGrande

✔️SuperAnfitrión Verificado ¡Tu estadía estará en las mejores manos! 🚨Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones especiales 📍 Apartamento en Isla Grande, Provincia de Colon, Panamá 🇵🇦 🏡 Espacio limpio, cómodo y seguro, con excelente ubicación 🧼 Dotado con insumos y productos de limpieza Durante tu reserva, tu Airbnb cuenta con: 🌐Wifi 📺TV 🍳Cocina 🌊Frente al mar ❄️A/C 🚗Parqueo 👉Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones

5.0 out of 5 average rating, 4 reviews
Guest favorite
The image captures a serene beach scene featuring a sandy shoreline and clear turquoise waters. Thatched-roof gazebos are visible near the water, alongside a wooden pier extending into the sea. Various boats are moored in the distance, surrounded by tropical greenery.
Vacation home in Maria Chiquita

Dreamy, Modern Caribbean Home at Playa Escondida

Have fun with the whole family at Casa Capri, a dreamy place which is a perfect fit both for adults & kids. The apartment is at Playa Escondida, a stylish resort with white sand beaches and crystal clear ocean water, several amenities such as a restaurant (with a broad range of great food, including fresh seafood and sushi!), pools to chill or swim, plus fantastic and diverse children playgrounds. Whether you'd like to have a resting vacation or a fun getaway, Casa Capri got you covered. Enjoy!

4.86 out of 5 average rating, 103 reviews
Top guest favorite
Place to stay in Panama City

Casa Condal - Your Luxury Retreat in Cerro Azul

Birdwatching • Romantic Getaway • Remote Work Escape the city. Breathe pure mountain air. Reconnect with nature. Casa Condal - private, modern, sustainable and regenerative hospitality inside Chagres National Park WiFi 65" Smart TV. Sound Bar Self check-in Private parking Fully equipped kitchen 220mts. private trail Deck-Mirador + FirePit, panoramic view of the mountains and valley King bed + Full size sofa bed BBQ Wheelchair accessible 40 min from Tocumen Airport. 1 hr from Panama city.

5.0 out of 5 average rating, 28 reviews
Superhost
An aerial view showcases a rustic cottage surrounded by lush palm trees, located near a sandy beach. The gentle waves of the ocean are visible, along with several red-roofed structures nestled within the greenery, creating a serene coastal atmosphere.
Cottage in Palenque

Beachfront House in Caribbean sandy beach

Enjoy this rustic and cozy cottage with its almost private beach surrounded by beautiful palm trees along the whole area. With 2 oceanview bedrooms, 2 full bathrooms and a third bedroom in a mezzanine. Has a patio with a built in uruguayan parrilla, ideal for BBQs. Step in beautiful white sand and bath in crystal clear water. Coconut breakfasts watching the sunrise become a routine in this paradise. - This is a rural setting. Not a 5 star hotel. Insects and small animals can be around.

4.88 out of 5 average rating, 96 reviews
Superhost
Home in Mechi

Beachfront Home | En-Suites + Chef & Tours Avail

Wake up to the sound of the waves… More than a beachfront home, Zola Sol is a curated wellness and lifestyle experience, thoughtfully designed around you. Whether you’re looking to relax, reconnect, or celebrate, we can personalize your stay with experiences such as private chef, wellness services, juice offerings, boat tours, and more—all seamlessly arranged before or during your visit. Your Airbnb reservation is simply the first step in creating an unforgettable Zola Sol experience.

4.73 out of 5 average rating, 11 reviews
Top guest favorite
An outdoor terrace features a table with seating for four, framed by colorful chairs in red and blue. A hammock is suspended nearby, with the serene view of the water and distant hills providing a tranquil backdrop. Natural light illuminates the space, highlighting the coastal setting.
Home in Juan Gallego

Beachfront · Large Sea View · Family Friendly

Welcome to Kasa Leilani, a charming beach house nestled between the jungle and the reef in the heart of a natural park. With stunning views of the nearby Caribbean islands, this peaceful retreat offers the perfect blend of nature and comfort. Surrounded by abundant wildlife, you can relax, explore the reef, or discover the island and crystal-clear waters. Kasa Leilani provides a serene escape for nature lovers and beach enthusiasts alike, offering an unforgettable tropical getaway.

4.94 out of 5 average rating, 99 reviews
Guest favorite
A serene swimming pool is depicted surrounded by lush palm trees, with the tranquil sea visible in the background. The water's clear blue tiles reflect the sky and nearby greenery, while the gentle curvature of the pool edge invites relaxation.
Villa in Portobelo

Entire Villa with pool in front of beach!

Beautiful spacious 4 bedroom villa right in front of the sea. Enjoy the swimming pool with your family, then take a dip into the sea only steps away. Very pet friendly! Take a boat trip for the day with a local certified tour guide from portobelo town. Every room has full AC, including the living room - but please be conscious of the environment when using ACs. Excellent WiFi ! Open Kitchen, with breakfast included. We can also arrange for lunch - fresh lobster!

4.97 out of 5 average rating, 88 reviews
Top guest favorite
The balcony offers expansive views of the ocean and nearby coastline, with palm trees visible along the shore. The scene features clear blue water meeting the sky, creating a serene atmosphere. Light hardwood flooring is present indoors, enhancing the open space leading to the outdoor area.
Apartment in Maria Chiquita

Amanecer Caribe at Playa Escondida Resort & Marina

Welcome to our inviting beachfront condo at Playa Escondida Resort & Marina in Maria Chiquita, Panama. Indulge in stunning ocean vistas from the private balcony, direct beach entry, and refreshing pools. Ideal for both relaxation and adventure seekers. Stay connected with complimentary high-speed WiFi, and indulge in your favorite shows or movies on the flat-screen TV. Reserve your tropical escape today and experience the beauty of Panama's coastline!

5.0 out of 5 average rating, 92 reviews
Top guest favorite
A bright living area features large glass doors that provide a panoramic view of the beach and ocean. A spacious sectional sofa is positioned near natural light, complemented by a wooden dining table. Elegant decor elements include woven light fixtures and fresh greenery.
Condo in Maria Chiquita

Playa Escondida with the Best Direct Ocean View

Wake up to the Caribbean blue from your private balcony, coffee in hand. Enjoy direct beach access, breathtaking ocean views, and a peaceful escape just one hour from the city. 4 rooms & 4 bathrooms ⭐ Premium - Fully stocked kitchen - In-unit washer and dryer - Nespresso/Drip/French Press coffee machine - High-speed WiFi - Ergonomic desk and office chair - Baby crib - High chair (baby)

4.99 out of 5 average rating, 95 reviews
Superhost
Two comfortable chairs are positioned on a tiled patio, facing an open gazebo by the sea. The gazebo's blue roof contrasts with the natural surroundings, and sunlight reflects off the water, enhancing the serene setting.
Cottage in Portobelo

Oceanfront House in Portobelo | SkyBluebyGuanche

Escape to an oceanfront paradise in Portobelo Leave daily stress behind at SkyBluebyGuanche, a cozy home surrounded by tranquility, lush greenery, and the soothing sound of the ocean. Situated on the beautiful coast of Portobelo, this property is the ideal retreat for families, couples, or groups of friends looking to unwind, enjoy the sea breeze, and take in unforgettable sunsets.

4.81 out of 5 average rating, 94 reviews

Popular amenities for Isla Drake vacation rentals