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Vacation rentals in Guadalupe

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Guadalupe

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
An open living area is observed, featuring a futon couch, a dining table, and a television. A neatly arranged kitchenette is equipped with essential appliances, and a spacious bed is seen in the corner. Ample natural light enters through two windows.
Loft in Nipomo
4.94 out of 5 average rating, 857 reviews

Upstairs Guest Loft~EV Charge/Non-smoking/Pet-free

Private upstairs loft includes kitchenette, full bathroom, deck, and separate entrance. Grizzl-E Classic 40A EV Level 2 charger (Type 1/SAE J1772) with NEMA 14-50 and 6-50 plugs. Non-smoking, pet-free property. In the heart of CA's Central Coast between Los Angeles and San Francisco. Only 2 miles off Highway 101. Close to Pismo Beach, wineries, and golf at Monarch Dunes, Black Lake, and Cypress Ridge courses. Easy access for road trips, weekend getaways, and relaxing stays year-round. No AC.

Guest favorite
Apartment in Santa Maria
4.88 out of 5 average rating, 95 reviews

Pet Friendly, Centrally Located w/ Shared Gym

Welcome to The Jungalow, a beautiful 1 bed/1bath apartment style home nestled in the “Loft District'' of Santa Maria! This home features an inviting bedroom and a spacious living area with ample natural light. You are minutes away from the 101, shopping, and local restaurants. Santa Maria is centrally located, just an hour from Santa Barbara and about 30 mins from San Luis Obispo, Solvang & Chumash Casino! Enjoy being close to beautiful beaches, hiking trails, golf courses & renowned wineries.

Top guest favorite
A spacious living area features a large sectional sofa in dark leather, situated near multiple windows allowing natural light. A wooden coffee table is placed at the center, accompanied by decorative items. A flat-screen TV is mounted on the wall, adding to the entertainment space.
Guesthouse in Santa Maria
4.97 out of 5 average rating, 153 reviews

Private top floor spacious 1 bedroom retreat

Forget your worries in this spacious and serene space. Following CDC guidelines, we make sure your stay is a safe & enjoyable one. Equipped with a gas range stove, microwave, and washer/dryer. Relax in a full size tub, walk-in closet & plenty of space to store your items & gear. Enjoy hiking, biking & disk golf at near by Waller Park! Private entrance & exit. Please read our rules below before booking: 2 guests max 1 car parking No Parties No Smoking No Pets Additional fees may apply

Guest favorite
Home in Santa Maria
4.95 out of 5 average rating, 58 reviews

Hogar, cómodo para descansar y relajarse Welcome

Desconecta de tus preocupaciones en este espacio tan amplio y sereno. En un vecindario tranquilo en donde puedes relajarte con toda Tu familia fácil de encontrar cercas de entradas y salidas para el Freeway, muy cerca de las tiendas en donde puedes hacer tus compras fácilmente. Todo está muy céntrico. En este hogar no se permiten ningún tipo de drogas rompes la reglas inmediatamente serás desalojado de este hogar. Si cumples con los requisitos. Bienvenidos gracias y que tengas buen día!

Top guest favorite
A cozy studio space features a spacious bed draped with a light canopy, complemented by soft linens. Natural light floods in through two windows, while a comfortable seating area with decorative pillows and a side table adds to the inviting ambiance.
Guest suite in Arroyo Grande
4.92 out of 5 average rating, 578 reviews

Cozy beach-themed studio with private patio

Relaxing, cozy beach-themed retreat designed for beauty & comfort. If having a restful and comfortable place to stay is important to you, as well as saving money, than this is the place for you. As 23-time Superhosts we have provided everything you may need for a great stay. The space is sparkling clean & offers the softest of linens, blackout curtains, extra pillows and soft blankets. Decorated with colors and decor of the ocean, we are sure you will feel all your worries drift away.

Top guest favorite
A small outdoor table is situated in a serene garden setting, featuring two wine glasses filled with red wine and a bottle nearby. A potted succulent adds a touch of greenery, surrounded by various plants, creating a tranquil atmosphere for relaxation.
Home in Santa Maria
4.96 out of 5 average rating, 132 reviews

Cozy Plant-Filled Loft in Orcutt

Stylish, plant-filled loft on the Central Coast! Relax under cozy lights surrounded by greenery in this peaceful, thoughtfully designed studio with everything you need. Enjoy a comfy living area with TV, kitchenette, WiFi, and private entrance for easy access. Located just minutes from Old Orcutt’s coffee shops, wine tasting rooms, and restaurants, with quick access to Solvang, SLO, and beaches. Perfect for a quiet getaway, work stay, or exploring the beautiful Central Coast.

Top guest favorite
Guesthouse in Santa Maria
5 out of 5 average rating, 12 reviews

Stunning Guesthouse with Private Entry & Courtyard

Welcome to our stunning, brand-new guesthouse—a serene and stylish 1-bedroom, 1-bath retreat designed to make your stay unforgettable. Located in Orcutt, CA, this cozy haven offers the perfect base for exploring the beauty of the Central Coast. Just a short drive from Santa Barbara (60 minutes), Pismo Beach (30 minutes), Vandenberg (25 min), and countless local attractions, this quiet neighborhood getaway is ideal for both leisure and business travelers.

Guest favorite
A wooden walkway leads through lush greenery, creating a natural archway. The bright sunlight filters through the leaves, illuminating the path. At the end of the walkway, a glimpse of the main house is visible, framed by vibrant plants.
Farm stay in Nipomo
4.88 out of 5 average rating, 602 reviews

Central coast paradise with forever views!

Large spacious private apt on a rustic, gorgeous property. Television High speed internet, pick fresh fruit, and lovely places to sit and relax. This beautiful place is an experience, to enjoy. Fridge, microwave, stove, oven, tea kettle and Keurig coffee maker. Enjoy the beautiful sunsets from the viewing deck or hot tub. Koi pond, chicken coop and free roam peacocks. Close to beaches, restaurants, wineries, wedding sites. Children and pets welcome.

Top guest favorite
A well-appointed sleeping area features a spacious bed dressed in a light-colored patterned coverlet. Stylish decorative pillows are arranged neatly at the head of the bed. A round table with a single chair sits nearby, surrounded by floral drapes that frame the window.
Guesthouse in Santa Maria
4.99 out of 5 average rating, 1,710 reviews

French Country Casita - Breakfast Included

This stand-alone casita sits in the privacy of our rear yard and has a separate entrance. We are three minutes from highway 101 in the newer La Ventana community. Surrounded by beautiful mountain views on the Central Coast and close to many flourishing wineries, this residence is 20 minutes south of Pismo Beach, 30 minutes from San Luis Obispo, one hour north of Santa Barbara, close to the beautiful Danish city of Solvang and Santa Ynez.

Top guest favorite
A small wooden table with two patterned chairs is positioned on a balcony, offering views of the expansive vineyard below. A bottle of wine and two glassed are set on the table, with rolling hills and distant mountains framing the picturesque landscape.
Guesthouse in Los Olivos
5 out of 5 average rating, 110 reviews

Los Olivos Wine Country Getaway

Wine Country living at its best! We enjoy our wine country life and would like to share it with you. Our two-bedroom, two-bath cottage has our CCOF certified organic Syrah vines as a backyard and its own private bocce ball court. Enjoy the setting of our vineyard right out the french doors or from the upstairs deck. A short stroll or ride on our complimentary bikes will take you to the heart of the historic charming town of Los Olivos.

Top guest favorite
A cozy living space features a built-in seating nook with striped cushions, surrounded by large windows that invite natural light. A round table with a woven tray and a plant adds a touch of greenery, while a mirror reflects the warm wood ceiling.
Tiny home in Nipomo
4.98 out of 5 average rating, 129 reviews

Modern + Cozy Oaks Hideaway

At our special spot, you get the best of both worlds: clean, modern and comfortably appointed tiny home on an oak-studded ranch surrounded by nature. Close enough to town, beaches, wineries, and restaurants for convenience while being far enough away to relax. Check out the creative and flexible spaces on the inside (living space coverts via Murphy bed to a queen bed sleeping area) and the comfy back patio for outdoor enjoyment.

Guest favorite
A bright living room is presented with natural light streaming through a window. Two comfortable chairs with soft throw blankets face a modern TV mounted on a pale wall. Decorative plants enhance the space, complemented by a wooden coffee table and light hardwood flooring.
Home in Arroyo Grande
4.93 out of 5 average rating, 256 reviews

Mid-century home in the heart of Arroyo Grande.

Welcome to the Eman House! I can't wait to host you at the 1950's mid century in Arroyo Grande, CA. Enjoy the beautiful remodeled kitchen, private backyard and patio, and two cozy bedrooms while soaking up the best of the central coast. Just a 10 minute walk to the historic Arroyo Grande village, a 5 minute drive to the beaches of Grover, and tucked away in one of Arroyo Grande's most peaceful cul-de-sacs.

Popular amenities for Guadalupe vacation rentals