
House vacation rentals in Guadalupe
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Top-rated house rentals in Guadalupe
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Beach-themed farmhouse with indoor fireplace
As 23-time Superhosts- we welcome you to the perfect place to relax & unwind after your day. This stylish and spacious home offers a sunny deck, surrounded by trees for sunbathing or watching the sunset. The huge 2nd bdrm is a great place for reading in our hammock chair or for a quiet work space. Downstairs the fully equipped kitchen has everything you need for cooking meals. Outdoor patio is a nice place to bbq & relax as you listen to the hawks, owls, & other birds in this country setting.

Coastal Getaway, Country House, near 101 FWY
Country house surrounded by trees with many windows, wooden floors, lovely kitchen, large sunroom, and huge deck. All located just minutes from Pismo, Grover, Shell and Avila Beach, hot springs, hiking areas, wineries, golf courses, Lake Lopez, ATV riding & outlet shopping, Trader joe's and many other stores. San Luis Obispo is a lovely city just minutes north. and Hearst Castle is less than an hour's drive North. Conveniently situated off the 101 freeway, a nice retreat from the big city.

Great outdoor space, King suite, EV Charger, A/C
Come relax and enjoy our peaceful home and outdoor spaces. We are located halfway between Los Angeles and San Francisco. Here you can experience the beautiful Central Coast including wineries, Beaches, Cal Poly and golf courses. We are located in a quiet neighborhood adjacent to an organic blackberry farm. Easy access to the 101 Freeway, where you can easily visit Santa Barbara or Paso Robles wine regions. Our home is FULLY Air Conditioned and features a level 2 Tesla charger for EV cars.

Gateway to SLO County with Pickleball & Game Room
Family fun awaits at this 4500 sq feet home base to explore everything that San Luis County has to offer. Originally a log home, the home has been tastefully updated throughout the years and has a spacious open layout. There are 4 bedrooms, 3 bathrooms, a theater room, a game room and covered patio. There's something for everyone in the backyard with sports court, fire pit and bocce ball. Walk 2 minutes to 140 acre Nipomo Regional Park with new skate park & tennis and basketball courts.

Working Ranch~Golf, Beach,Wine/No smoking/Pet free
***At this time we are not set up to host weddings or public events.*** Escape the city to this ranch retreat surrounded by working farms. This 3-bedroom, 4-bath vacation home is on a full-time ranch in the heart of California’s Central Coast, halfway between Los Angeles and San Francisco, just 2 miles from Highway 101. Golf, wineries, and hiking are minutes away. Avila Beach, Pismo Beach, Cal Poly and San Luis Obispo are a 15–20 minute drive. Stays of 30+ days available upon request.

San Luis Obispo Wine Country Retreat
Escape to a charming three-bedroom farmhouse on a shared 10-acre ranch in San Luis Obispo's Edna Valley. Newly renovated with modern amenities including a spacious kitchen, cozy living room with smart TV, and private patio with fire pit. Sleeps up to six guests with stunning views of rolling hills. AC, heating, WiFi, and BBQ grill included. Explore nearby wineries and restaurants or relax on the private patio. Long term stays allowed. Book now for a memorable California getaway.

Casa Del Mar
Enjoy a little getaway in this cottage by the beach. It’s cozy and simple with all the features of comfort. Walking to the beach is a just a short stroll down a windy little road filled with cool beach vibes. Cross a little wooden bridge and walk down a block or two and you are right in front of the Oceano dunes. Plan a bonfire and make s’mores on the beach. Or better yet, stay at the little cottage, grab a bottle of wine and enjoy a fire pit right outside your bedroom door.

Cozy Plant-Filled Loft in Orcutt
Stylish, plant-filled loft on the Central Coast! Relax under cozy lights surrounded by greenery in this peaceful, thoughtfully designed studio with everything you need. Enjoy a comfy living area with TV, kitchenette, WiFi, and private entrance for easy access. Located just minutes from Old Orcutt’s coffee shops, wine tasting rooms, and restaurants, with quick access to Solvang, SLO, and beaches. Perfect for a quiet getaway, work stay, or exploring the beautiful Central Coast.

Blue Laguna Landing
Welcome to Laguna Landing! Located only steps away from the Oceano Dunes and Pismo Beach is this large 2900 square foot home. Drive to the town close by or kick back and relax at the beach or take in views from the balcony. Please see the full description for more details. "Check midweek rates if you have travel flexibility." We have made some updates to the home Dark blue is new color. New TV's, kitchen table, outdoor furnishing, kids beach toys. Cars do drive on this beach.

Luxe Hideaway: Prvt Patio BBQ Winery, 20 min-Beach
Agreement: Bookings require a signed Renter Agreement, please check your email to complete booking. Kick back & relax in this calm, modern space. Enjoy the privacy of your own home with contactless check-in, high speed internet, comfortable beds, pull-out memory foam sofa sleeper for added guests, full kitchen just waiting for your culinary desires, and a patio with dining set for 6. Enjoy being centrally located while you explore the beautiful central coast.

Mid-century home in the heart of Arroyo Grande.
Welcome to the Eman House! I can't wait to host you at the 1950's mid century in Arroyo Grande, CA. Enjoy the beautiful remodeled kitchen, private backyard and patio, and two cozy bedrooms while soaking up the best of the central coast. Just a 10 minute walk to the historic Arroyo Grande village, a 5 minute drive to the beaches of Grover, and tucked away in one of Arroyo Grande's most peaceful cul-de-sacs.

Beach home near golf, wineries, dunes & Vandenburg
This Pasadera home has three bedrooms two and a half bathrooms with a loft which has a fold out couch. The downstairs couch will sleep 2 more if needed so 9 people will fit. It’s just a few miles away from Trilogy and Blacklake golf course, the beach, shopping , golf courses and many wineries! It’s a perfect beach community. About 20 minutes to Vandenburg Air Force base.
Popular amenities for Guadalupe house rentals
House rentals with a pool

Pool & view in Sta Rita Hills Wine Country, Lompoc

Spacious SLO CAL Home w/ Pool, Spa. Pet Friendly!

San Luis Obispo House With Pool And Hot Tub

Getaway at the Highlands+Heated Pool+Hot Tub

Heated pool (82 degrees), hot tub, gas firepit

FairView Lavender Estate

Ranch Style Home w/ Bikes! Heart of Wine Country

Historic 1895 Edna Railhouse with Heated Pool
Weekly house rentals

Mid Century Modern Loft Downtown SLO

Central Coast Getaway

Oceano Home with a View

Harbor House in Morro Bay

1884 Elegant Home: Fire Pit, Tesla Tech, Near DT

Quiet Oaks Bungalow

In the Heart of Los Olivos

|Safe|BBQ | Hot Tub| 4 Bedrooms| Deck With Views
Private house rentals

Brand New! Close to 101!

Chorro St. Bungalow

Entire Home - Luxurious California Coastal Retreat

Happyfam Country Home Near Coast

Harrison Hide Away 2 bedrooms

Nipomo Getaway

La Ranchita Wine Country Equine retreat and Spa

Cozy house in Edna Valley wine country near SLO
Destinations to explore
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- Cayucos Beach
- Montaña de Oro State Park
- El Capitán State Beach
- Morro Strand State Beach
- Cayucos State Beach
- Pismo State Beach
- Morro Rock Beach
- Morro Bay Golf Course
- Solvang Windmill
- Mission San Luis Obispo de Tolosa
- Los Padres National Forest
- Oceano Dunes State Vehicular Recreation Area
- Dinosaur Caves Park
- Charles Paddock Zoo
- Pismo Preserve
- Monarch Butterfly Grove
- Sensorio
- Vina Robles Amphitheatre
- Tablas Creek Vineyard
- California Polytechnic State University
- Downtown City Park
- Austin Hope Winery
- Nojoqui Falls Park
- Niner Wine Estates





