Vacation rentals in Effingham

A decorative arrangement is displayed on a white mantel. A framed painting of a flower vase is positioned alongside a woven basket and a circular ornamental piece, adding a touch of charm to the space.

4.87 out of 5 average rating, 495 reviews

Kuker Cottage Downtown Florence-Near I95 & I20

Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

5 out of 5 average rating, 117 reviews

A bedroom featuring a spacious bed with a patterned coverlet and a large dresser with a flat-screen television. A piece of wall art depicting trees is displayed above the dresser, and a doorway leads to a bright bathroom visible in the background.

Home in Hartsville

Manchester Place

Hartsville is a Charming Town with plenty of family activities, shops, and dining. Home is located in the quiet Fox Hollow subdivision which is just outside the city limits but still close to downtown. Robinson Nuclear Plant 10 min. Sonoco 7 min. Coker University 7 min. Downtown Hartsville 7 min. Carolina Pines Hospital 9 min. McLeod Hospital Florence 42 min. Byerly Park 9 min. Hartsville Center Theater 6 min. Governor's School for Science and Mathematics 9 min. Darlington Raceway 22 min.

Superhost

A bathroom cabinet is shown with an open door, revealing three bottles of personal care products. The items include a bottle of shampoo, a bottle of conditioner, and a bottle of body wash, all neatly arranged on a white shelf.

4.9 out of 5 average rating, 10 reviews

Calm condo extra large and carport

This stylish place to stay is perfect for any trip. Upgraded kitchen, open concept, barn door third bedroom closure. Perfect for those who share beds. HDMI ROKU 4K TVs, en-suite shower in primary bathroom, grassy enclosed back yard, convenient to I-95 and I-20 interstate highways. Less than 5 miles to Florence-Darlington Technical College. Less than 5 miles to anything inside city limits. Less than 10 miles to Florence Regional Airport. Less than 15 miles to Francis Marion University.

Place to stay in Effingham

A shaded outdoor deck area features a wooden pergola with vines above. Four wicker chairs with floral cushions surround a small table, creating a cozy seating arrangement. The background includes a wooden gate and lush greenery, enhancing the space's natural ambiance.

4.97 out of 5 average rating, 138 reviews

Gated and Private Catholic Hermitage house

Saint Michael Hermitage and retreat is a serene, gated, private home that is for 1-3 guests looking for a quiet stay while traveling or as a retreat destination. You will self check into your Hermitage after you obtain a gate code. There is a prayer chapel close by on the property. It is pet friendly for a well trained pet. There is Catholic iconography throughout the home. It is warm and inviting. There is a full kitchen, washer/dryer for your convenience and complementary coffee/tea.

4.93 out of 5 average rating, 88 reviews

Charming Home in Florence, SC

Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.

4.97 out of 5 average rating, 954 reviews

A large tree with a thick trunk and abundant green leaves creates shade over a grassy area. Surrounding the tree are several smaller trees, contributing to the serene, open landscape that defines the peaceful outdoor setting.

Cottage in Timmonsville

*Cottage Near Florence and I-95* 3 Bedrooms

Located just 5 mins from I-95 (exit 153) and 12 minutes from Florence, this quaint cottage sits on 6 acres with private deck, firepit & large back yard in a peaceful, country location. Your pets are welcome (max of 2, please). We offer king bed in master, 3 wall-mounted TV's (two 55” & one 32”), coffee bar with Keurig, strong WiFi. We also use 100% cotton sheets and quilts for your maximum sleeping comfort. Absolutely no smoking ON OUR PROPERTY ($200 extra fee). Come stay with us. 🙂

4.93 out of 5 average rating, 242 reviews

A bathroom is depicted showcasing a clear shower curtain revealing a bathtub behind it. The walls are framed with warm wood accents, enhancing the overall texture of the space. A toilet is positioned to the left, completing the functional layout of the bathroom.

Home in Lake City

Home Away From Home Apt 3 - A Hidden Gem

Stand Alone (not a part of the main house) 1 Bed-Room Apt. with Full furnished Kitchen, Full Bath, Private Entrance, private bedroom with door, Private Parking. Living Room- Dining Combo. Fully Furnished. High-Speed WI-Fi, 2 ROKU TVs, 1 in BR & 1 in LR, 1/2 way from New York to Miami, Hablamos Espanol, Fresh Brewed In-Room Coffee. Easy 1-mile walk on Main St. to uptown. 23 miles from I-95, 60 miles to Myrtle Beach, 23 miles to Florence, 1&1/2 hours to Charleston and Columbia.

Farm stay in Timmonsville

A brown chicken perches on a wooden fence, set against a backdrop of a grassy farmyard and rustic barn. The scene captures the essence of farm life, with trees and structures softly blurred in the background.

4.95 out of 5 average rating, 635 reviews

The Cottage at Dream Acres & Petting Zoo I-95/I-20

The Cottage at Dream Acres is situated with its own private drive on our 8 acre working horse farm located near Florence SC at the I-20/ I-95 corridor, 5 mins off the highway. We are the 1/2 way point between NY & FL. Relax and unwind from a long roadtrip or take a weekend farm-stay getaway. All the amenities of a larger home with the convenience of a smaller space! Family Friendly; sleeps up to 4, newly renovated in 2020, petting zoo, outdoor fire pit, tree swing, picnic table!

4.98 out of 5 average rating, 815 reviews

A covered outdoor seating area features a wooden bench adorned with decorative pillows, complemented by two colorful chairs. The space is bordered by a grassy yard visible in the background, under the shade of a nearby tree.

Guesthouse in Florence

Boho Private Downtown Stay Near I-95 & Hospital

Comfort, cleanliness, privacy, and personality! Perfect for overnight stays or longer terms. Come enjoy our Boho hideaway in the heart of Florence. Our place has all the amenities of a hotel with the comfort and privacy of your own home including covered parking for two vehicles. We are located within walking distance to downtown Florence and a 5 minute drive to all of the restaurants and shopping that Florence has to offer. Come stay at our guest house and make yourself at home!

4.93 out of 5 average rating, 843 reviews

Open shelving displays an assortment of dishware. Colorful mugs are arranged alongside a white ceramic pitcher, while various bowls and plates in blue and floral patterns are neatly stacked above. A woven basket adds texture to the arrangement.

Guesthouse in Florence

The Cottage by the Pool: Close to Interstates

New floors and paint in January of 2023. Palm Trees, colorful flowers, hammocks and quiet space await in this tropic-like oasis just minutes from I-95/20. Hundreds of reviews acknowledge this idyllic setting. We are a Florence Airbnb favorite for travelers. We offer a queen bed, full bathroom, full sleeper sofa, strong wifi and TV. We even provide breakfast bars and coffee to help you jump start your day as you set off for the next journey. We look forward to hosting you.

5 out of 5 average rating, 272 reviews

A charming tree house is surrounded by snow-covered trees, showcasing a wraparound deck with wooden stairs leading to the entrance. Large windows allow views into the inviting interior, while snow blankets the ground, highlighting the natural setting.

Treehouse in Marion

Enchanting Treehouse with Modern Amenities

Perched on 20 acres along Catfish Creek, this enchanting tree house allows you to appreciate nature from a birds eye view. Whether it’s kayaking, canoeing, or exploring along the creek; relaxing in the hammocks and swings; engaging in a board game; or roasting marshmallows at the fire pit, Amenities include a full kitchen with full bath, outdoor shower, booth seating in dining table for up to 8, 2 bunk beds and loft style sleeping.

5 out of 5 average rating, 123 reviews

Home in Florence County

Highway Oasis and Myrtle Beach

Welcome to this charming new house ideally situated close to both a major highway i 95 and i20 and the serene Myrtle beach, offering the perfect blend of convenience . Nestled in a great neighborhood, this residence boasts easy access to shopping center, ensuring that all your daily needs are just moments away. Very close to Florence Civic Center, 15 minutes to Buc-ee's Myrtle beach in 1 hr of a drive and shopping amenities.

Vacation rentals for every style

Get the amount of space that is right for you

Hotels

Stylish accommodations and amenities

Unique stays

Spaces that are more than just a place to sleep

Homes

Comfortable places with all the essentials

Popular amenities for Effingham vacation rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Other great vacation rentals in Effingham

An interior view of a camper highlights a compact layout, featuring a seating area by a table and a television mounted on the wall. A door leads to a small bathroom area equipped with a toilet and a shower. A bunk bed is visible through a partially open door.

Guesthouse in Timmonsville

4.86 out of 5 average rating, 69 reviews

New camper with memory foam mattress on 1/2 acre

KristaRating, 5 stars1 week ago

Takisha’s place was a good spot to stop at off the highway and get some much needed rest.

5 out of 5 average rating, 7 reviews

A well-equipped kitchen counter features a Keurig coffee station alongside a red appliance. A clear canister with coffee pods is neatly arranged, with light streaming in through a window, illuminating the clean marble surface.

Condo in Florence

Roomy Top Floor Barndominium

JessicaRating, 5 stars11 months ago

Great spacious apartment with outdoor seating going out back into a nice and peaceful neighborhood.

An open living area features a cozy seating arrangement with a light-colored sofa beside a welcoming fireplace. A small dining table with two circular placemats accompanies a potted plant, while large windows allow natural light to fill the room.

5 out of 5 average rating, 10 reviews

Cozy One Story Town House

BrittanyRating, 5 stars1 week ago

Christopher’s was a very responsive and an amazing host! I came through a time where I had to cancel one of the nights due to personal reasons,and he was able to give me a full refund. Which is absolutely amazing. His home was very nice and clean, and is in a very good and peaceful neighborhood. The inside and outside of his home is beautiful, and I love how he has a fenced backyard. I totally recommend this home!

5 out of 5 average rating, 20 reviews

Peaceful Pine Stays/ 5 min. from Mcleod hospital

TorraRating, 5 starstoday

This house was beautiful 🥰🥰🥰 the kitchen was fully stocked with seasonings and all above the bed room was so beautiful

4.92 out of 5 average rating, 26 reviews

A well-appointed kitchen features white cabinetry complemented by granite countertops. Stainless steel appliances, including an oven and a refrigerator, are visible. Natural light floods the space through a window above the sink, while a textured area rug adds warmth to the wooden floor.

Home in Hartsville

Take it Easy 2 queens/2 baths

MaryRating, 5 stars3 weeks ago

Great stay! Loved the house and it’s a good set up for more than one guest. Friendly and great hosts!

A close-up view of a digital door lock is displayed, featuring a keypad with numbered buttons and a keyhole. The lock is mounted on a green door, showcasing a polished gold finish around the buttons and a prominent branding inscription.

Guest suite in Florence

4.84 out of 5 average rating, 482 reviews

Private Apartment 5 Min Away From I-95 & I-20

SuzetteRating, 5 stars2 weeks ago

It's like having your own tiny house. A really nice layout, big bedroom, nice kitchen/dining area, overall just very comfortable. Not far from a Walmart to get groceries & etc.

Superhost

A clean bathroom is designed with a dual sink vanity featuring a granite countertop. A large mirror reflects natural light. Dark curtains cover the shower area, while a small plant adds a touch of greenery. Neutral tiles create a calm ambiance.

4.78 out of 5 average rating, 63 reviews

Cozy 3 Bedroom Home! Located NEAR MUSC-Florence

GlennRating, 5 stars2 weeks ago

Shakeita was great throughout the process in regards to answering questions. Easy check-in/check-out. We've stayed here multiple times and will again. Great place!