House vacation rentals in Cherokee County

4.84 out of 5 average rating, 45 reviews

Home in Blacksburg

Cozy - 3 Bed room home with an indoor fireplace

Relax with the whole family at this peaceful 2 story place to stay. Located right beside the Broad river in the mill hill village and just a short 10 miles from limestone college and 20 miles from Gardner web, you can bring your kayaks and explore the various boat landing points up and down the river or you can go out to the various national trails in the area. You can also take a short 16 mile drive to the new near by casino. This is the perfect little get away for what ever your plans are.

5 out of 5 average rating, 19 reviews

Home in Cowpens off exit 83

Check out this beautifully renovated brick home just off HWY 85, exit 83! This residence features three spacious bedrooms and two full bathrooms, perfect for families or groups. Enjoy the convenience of a full-size washer and dryer, along with a fully stocked kitchen equipped with everything you need to whip up great meals. Conveniently located just 7 miles from the Gaffney Outlet and 10 miles from downtown Spartanburg, this home is perfectly positioned for both relaxation and exploration!

Superhost

4.75 out of 5 average rating, 8 reviews

Modern & Cozy | Near Downtown | 75” TV + Fast WiFi

Welcome to Cozy Home! This newly renovated 3-bedroom, 2-bathroom home in Spartanburg—blends comfort with convenience—perfect for families, couples, business travelers, or anyone seeking a peaceful getaway. Enjoy a fully stocked kitchen with new stainless steel appliances, ultra-fast WiFi, cozy living spaces, and thoughtful touches like a 75” smart TV and memory foam beds. Whether you’re here for work or play, Cozy Home is your base to relax, recharge, and explore the charm of Spartanburg.

Top guest favorite

5 out of 5 average rating, 9 reviews

Modern Country Comfort

Escape to this newly renovated modern hideaway just 20 minutes from Spartanburg! Inside, you’ll find a calming open-concept retreat with chic monochromatic style. Outside, rustic charm awaits—unwind under the carport hangout, sip coffee on the spacious deck, and soak in the peaceful sounds of birds by day and crickets by night. This home sleeps 6 comfortably with 2 bedrooms (king and queen beds), a futon, and a roll-away cot. Come relax, recharge, and enjoy the stillness of country life.

4.93 out of 5 average rating, 15 reviews

Peach Haven Hideaway

This beautifully remodeled 3-bedroom, 2-bath home with open floorplan, offers the perfect blend of convenience and comfort. Ideally situated 8 miles from Limestone University, 29 miles from the BMW Zentrum Center, 15 miles from the University of South Carolina Upstate, 28 miles from Tyger River Park, 32 miles from Greenville-Spartanburg International Airport, and 54 miles from Charlotte Douglas International Airport, this home provides easy access to major attractions and amenities.

Top guest favorite

4.93 out of 5 average rating, 353 reviews

beautiful nature,3bedroom, 2 king and 2 queen beds

Our home is located in beautiful neighborhood. We love our view. House has 3 bedrooms ( two bedrooms have king beds and one bedroom has two queen beds), also have two futons in living room that can be used as full size beds. This home was remodeled by my husband and me and were constantly adding new ideas to it. however, we do not tolerate any kind of wild parties that include hard liquor or smoking. absolutely no smoking in the house the wood in house will peneteate the smell.

4.86 out of 5 average rating, 56 reviews

Family/pet-friendly with ACRES of outdoor space!

You have found the perfect spot for your get away or extended stay in Spartanburg. “House of Blues” comfortably sleeps 8 guests and is pet & family-friendly! You’ll find yourself less than 15 minutes from downtown Spartanburg, and less than 5 minutes to great shopping, dining, and entertainment on East Main Street, as well as easy access to Interstate 85. Amenities include ample outdoor space with a large lawn, picnic table, and grill!

4.85 out of 5 average rating, 13 reviews

Baby Blue Bungalow with Backyard Oasis

At our baby blue bungalow you and your family can enjoy our private backyard oasis with the hot tub, fire pit, and grill. Take the fun inside with our ping pong table, board games, and open living space. You can also start your mornings off right by enjoying our self-serve coffee bar. With Downtown, restaurants, and parks nearby, you will be close to everything Spartanburg has to offer when you stay at this centrally-located home!

Top guest favorite

Home in Gaffney

5 out of 5 average rating, 24 reviews

Cottage On College

Discover the charm of the “Cottage on College Drive,” a cozy haven nestled on Historic College Drive in Gaffney, South Carolina. This beautifully appointed cottage offers the perfect blend of comfort, convenience, and tranquility—ideal for solo travelers, couples, or small families eager to explore the Upstate. Steps from Limestone University & downtown Gaffney’s restaurants, shops, and attractions.

4.92 out of 5 average rating, 110 reviews

Home in Gaffney

Cozy 2 bedroom home near downtown Gaffney.

Truly live like a local at Casita Gaffney! This cozy modern home sleeps up to 6 guests. Situated near the heart of Gaffney, our home is your relaxation destination. Conveniently located only minutes from I-85. Stocked kitchen for cooking and professionally cleaned. Our casa es su casa! This retreat is the ideal getaway for couples, friends, and small families to explore everything Gaffney.

5 out of 5 average rating, 24 reviews

Cozy Countryside

Unwind and recharge in the quiet charm of the countryside, just minutes off the interstate, yet far from the rush. Our cozy country home offers a warm welcome. Whether you’re stopping for a restful night, visiting family or planning a quiet weekend away, our home offers a peaceful space to slow down, connect, and breathe easy.