
Places to stay near 21c Museum Hotel
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Top-rated vacation rentals near 21c Museum Hotel
Guests agree: these stays are highly rated for location, cleanliness, and more.

2-BR apt/garden near downtown Durham arts & eats
A private, restful & artful 2-BR apt. hosted by one of fewer-than-20 Airbnb Belo Award winners in the world. 900 sq. ft. complete lower fl. of 1960s brick split-level on unpaved lane near park. Lush garden. Private entry; parking; lvng rm w/fireplace; bthrm/shwr; kitchenette only; generous amenities; wifi; TV. Superhost since 2014; 1,000 5-star reviews. 1 mi. DPAC/Durham Bulls; 1.5 mi. Carolina Theatre; 3 mi. Duke U/Med Cntr. No added cleaning fee. Host fully-vaccinated; same expected of guests.

Light-filled Guesthouse Near Duke
Second floor of recently-built garage apartment in a charming, peaceful Durham neighborhood. Twenty minutes to RDU Airport, five minutes to Duke's East Campus and ten minutes to West Campus, we are an easy walk to a range of locally-owned restaurants. Lovely, light-filled apartment has a bedroom, full kitchen and living area, bathroom, private entrance, and patio with seating. Occasionally, we may have first-floor space available at extra cost. Well-behaved pets welcome. See below for fees.

Modernist Masterpiece: 'Simply the Best'
Welcome to Hazel Modernist 6 - designed and built by Alicia Hylton-Daniel, with her "sister," Modernist 5, next door. Centrally located downtown, this gorgeous escape is truly livable. Fully equipped chefs kitchen opens into the large living & dining space, with Frame TV and fireplace. 3BR & private back deck offer plenty of space together or alone. Each home by Alicia is infused with creative and new design concepts. This glamorous home celebrates the essence of Tina Turner, Simply the Best.

Main St Studio w Rooftop Patio!
Literally right on Main St in downtown Durham! You'll be close to EVERYTHING! DPAC, Durham Bulls, Carolina Theater, amazing restaurants and cafes, American Tobacco Campus' stores, restaurants and unique walkway. It's all within 3 blocks! Enjoy sunrise OR sunset overlooking the famous Lucky Strike Water Tower from the cozy rooftop patio. Or stroll home in a matter of MINUTES from a baseball game or DPAC show. Perfectly appointed apartment w all you'll need to have a great and relaxing stay!

Walk to Duke or Downtown- 1st floor
Beautiful, nicely furnished 1st floor apt in a quiet neighborhood between Duke and Downtown Durham, walkable to both. Very comfortable beds with high thread count scent free linens. Fully equipped kitchen and bathroom with organic body wash, shampoo, conditioner, blow dryer & make up mirror. 2 miles from Duke and VA Hospitals. 2 blocks from restaurants and the Organic Co-op grocery store. Lots of well lit parking on-site. We hope you'll love the comforts and convenience of staying her

Tiny Farmhouse in the Heart of Durham
Enjoy the tiny experience without sacrificing the relaxations and comforts of home. Unwind in this quaint 1 bedroom 1 bath tiny farmhouse that’s equipped with full-sized appliances and tasteful amenities. The Farmhouse at Scout is nestled in Downtown Durham’s burgeoning Southside neighborhood and is extremely close to the best restaurants, shops, and activities that Durham has to offer. Major attractions: • DPAC: .8 mi • Durham Bulls: .8 mi • Farmer’s Market: 1.2 mi • Duke: 2.9 mi

Private studio apartment steps from Downtown!
Compact studio steps from Downtown Durham with a private entry and free street parking! Well-stocked kitchenette and bathroom. Close to Duke and walkable to all of Downtown and more: ✦ 7+ coffee shops ✦ 10+ breweries ✦ Plenty of restaurants + bars ✦ DPAC, Durham Bulls + Durham Convention Center ✦ Central Park, Farmer's Market + Durham Food Hall ✦ Ellerbe Creek + American Tobacco Trails We live in the townhouse above the studio and are happy to assist with anything you might need.

Luxurious Modernist Tree House
Stunning, private, and truly one-of-a-kind—this unique home is perfect for a vacation, staycation, special occasion, or simply celebrating everyday life. Designed by renowned modernist architect Frank Harmon. The 2,128-square-foot residence sits on 1.3 acres and was crafted with meticulous attention to detail. Inside, you’ll feel nestled among the treetops while remaining conveniently close to restaurants, shopping, downtown Raleigh, WakeMed, UNC, Duke, and Research Triangle Park.

Modern Tiny House Near Duke & Downtown
You’ll feel like you’re getting away from it all in this modern, private tiny house in the trees, even though you’re just minutes from Duke, downtown Durham, shopping, and restaurants. It’s the perfect balance of peaceful retreat and city convenience. The home includes all the essentials — full kitchen, laundry, A/C, and high-speed internet — but many guests find themselves spending most of their time relaxing on the screened-in porch, listening to birds, and recharging.

Five & Dime Tiny House
Experience the charm of tiny living in this pet-friendly studio located in my serene yet urban backyard. It offers a peaceful escape while remaining convenient to the attractions & amenities that Durham has to offer. -only a mile east of downtown -1.5 miles to DPAC and Carolina Theatre -ten minutes to both Duke Hospital and Duke Regional -less than 20 minutes to RDU airport Let your dog run around the fully fenced yard while you sit on the deck and sip your coffee!

Duplex filled with natural light
A stylish, modern, and beautiful alley guesthouse that is located just 2 blocks from Duke's East Campus and 4 blocks from downtown Durham. The apartment is located in the historic Trinity Park Neighborhood in Durham. The apartment has a top of the line finish, hardwood floors, appliances, and furniture. The loft area is equipped with a standing desk and monitor and 2 Yoga matts, and it is ideal for working professionals visiting the area. Built: 2023

Garden Oasis in the heart of downtown Durham
Beautifully renovated must stay if visiting Durham downtown. Within walking distance of many restaurants and city sites. Close to Duke Medical and Campus, and a stone's throw from many of the great restaurants and activities downtown has to offer. Pearl mill (122) offers a secret garden courtyard, an oasis of serenity amongst the action of the city. Huge pool to enjoy, March through October, weather permitting.
Popular amenities for vacation rentals near 21c Museum Hotel
Condo rentals with wifi

Second floor 1 BR condominium near The Village

A short walk with a breeze .

Condo @ Historic Duke Tower

Downtown "Bull Durham" Condo

Cute Condo Near Downtown

Warehouse District Modern Condo w/ Private Garage

Near Downtown Cary 2 | King Beds | Huge 75” TV

Carrboro/Chapel Hill/UNC bright contemporary condo
Family-friendly house rentals

Near Duke, Southpoint, UNC

Cottage with Yard, Mins to Duke

Luxe Modern Retreat *Entire Duplex/ Both Units!*

Clean Quiet Medical&Work Stay, Fenced Yard, Pets

Cozy Cottage with Fenced Yard

Mirabelle- 3bd Downtown/Duke/RTP/No Cleaning Fees

The Angier House | Modern Smart Home | 4Car Garage

Full reno, walk to restaurants!
Apartment rentals with air conditioning

Back Alley Apartment, walk Downtown and Duke.

The Loft @ Casa Azul - Studio Apartment

Bull City Apts near Downtown / Duke - Trinity 01

Downtown Durham Retreat

Heel-O Sunshine

The Artist's Garret at Fearrington

Dollar Avenue Treehouse near Duke

Walk to Duke Campus! 1 Bedroom in Trinity Park!
Other great vacation rentals near 21c Museum Hotel

Modern Cottage With a Vintage Twist Near Downtown

Full floor suite in historic Durham neighborhood

Bergamot Short Stay Flat

Bright Downtown Gem: Modern Luxury - 5min Stroll

Luxury in the heart of Downtown!

New Bohemian Studio Tiny Home

The Durham Blue Bungalow- Walk Downtown

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Destinations to explore
- Duke University
- University of North Carolina at Chapel Hill
- PNC Arena
- Raven Rock State Park
- Durham Bulls Athletic Park
- American Tobacco Campus
- Lake Johnson Park
- Eno River State Park
- North Carolina Museum of Natural Sciences
- North Carolina State University
- North Carolina Museum of Art
- Sarah P. Duke Gardens
- Frankie's Fun Park
- North Carolina Museum of History
- Raleigh Convention Center
- William B. Umstead State Park
- Carolina Theatre
- Crabtree Valley Mall
- Durham Farmers' Market
- Elon University
- Virginia International Raceway
- International Civil Rights Center & Museum
- Museum of Life and Science
- Duke Chapel




