House vacation rentals in St. Clair County

Find and book unique houses on Airbnb

Top-rated house rentals in St. Clair County

Guests agree: these houses are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Home in Millstadt

4.94 out of 5 average rating, 232 reviews

Deluxe Barndominium | King bed + Pkg

Enjoy the unique historical setting of this recently remodeled Barndominium, just 5min away from DT Millstadt and 20min from DT St. Louis. Learn the old Illinois ways by relaxing in a contemporary decorated barn that was once an honor system farm stand. Blend of comfort, stylish décor & a rich amenity list are there to satisfy your every need. ✔ 2 Comfy Bedrooms (King Bed, Single over Double Bunk) ✔ Fully Equipped Kitchen ✔ Open Living Area ✔ 55’’ Flat-Screen TV ✔ Fast internet See more below

Jan 7 – 14

G$24,711 GYD per night

Guest favorite

Home in St. Louis

4.94 out of 5 average rating, 223 reviews

Art Inspired Home, Great Beds! -Near CWE/BJC/Grove

Welcome to one of STL's' most inviting & unique Airbnbs! Our home has just been completely remodeled with all the modern conveniences & is located minutes from the CWE, BJC Hospital, The Grove entertainment district, Botanical Gardens, Tower Grove Park, & so much more! The home has a rear bedroom, 1 pass-thru bedroom in the middle of the home, and a living room with 2 pull-out couches. The home includes:,W/D, yard, pond with fountains! Did I mention, Pac-man with 60 games? Come see for yourself!

Sep 14 – 21

G$26,307 GYD per night

Guest favorite

Home in Mascoutah

4.96 out of 5 average rating, 392 reviews

The Doll House

Welcome to our Victorian doll house! Listed on the National Register of Historic Places, it maintains its original features yet is updated with modern conveniences. The kitchen is fully equipped, coffee, tea and bottled water are provided. Wifi is available and the home is within walking distance of restaurants and shopping. Enjoy the nice peaceful backyard while you sit on the porch & relax with your cup of tea or glass of wine. An easy drive just 4 miles south of I-64. Weekly discount 14%.

Feb 19 – 26

G$18,822 GYD per night

Guest favorite

Home in St. Louis

4.94 out of 5 average rating, 913 reviews

ArtBnB: Enjoy the Curated Comforts of Home

With easy highway access, and conveniently situated equidistance from Soulard, Lafayette Square, Tower Grove South, and Cherokee St, this custom designed space is not only an experience on its own, but a perfect base for exploring The Gateway City. Surround yourself with art, literature, and the homie comforts that set ArtBnB aside from staunch hotel chains. A lightly stocked kitchen, library, garden, patio, deck, grill, fire pit, wine rack, kennel, toiletries, and parking pad are all included.

Dec 14 – 21

G$18,823 GYD per night

Guest favorite

Home in St. Louis

4.96 out of 5 average rating, 248 reviews

Lil' Grove Home -- Modern, Comfy, Kid-Friendly 2BR

Clean, modern, cozy space in The Grove neighborhood! Very kid-friendly! Pack n'Plays, high chair, etc. New play space/game room! Less than 1 mile from Barnes Hospital! In the vibrant Forest Park Southeast neighborhood of STL. Steps away from a number of restaurants and bars, including the award-winning Urban Chestnut Brewery, the house is also very close to the Central West End, Cortex, The Hill, WashU, SLU, and Forest Park. Is a 15-minute drive or less to just about anywhere in the city!

Jun 13 – 20

G$27,095 GYD per night

Guest favorite

Home in St. Louis

4.91 out of 5 average rating, 400 reviews

The 1904 WORLD’S FAIR RETREAT

The World's Fair Retreat will not only give you one of the most unique and enjoyable stays in the Midwest, but it will also take you back in time to 1904 when St. Louis was not only a major industrial empire, but a crown jewel of the ENTIRE WORLD - thanks to the 1904 World's Fair held in the Forest Park of St. Louis. This retreat is situated in the cozy & hip Tower Grove East neighborhood, where true STL city locals live, shop, eat, drink, and be merry! A one-of-a-kind St. Louis experience!

Jan 22 – 29

G$23,182 GYD per night

Guest favorite

Home in St. Louis

4.93 out of 5 average rating, 117 reviews

Beautifully renovated 1890s artist's home

Freshly-rehabbed, clean and charming historic home near the quiet side of Cherokee Street, St. Louis' hippest and most diverse neighborhood. A minute's walk from Mudhouse (excellent breakfast and coffee), antique stores, restaurants, bars, and the lovely Victorian-era Benton Park. Conveniently located a few minutes from the highway - get everywhere in St. Louis region quickly. Enjoy my eclectic library of fiction, non-fiction and graphic novels, and my TV has Roku with Netflix and Hulu!

G$16,853 GYD per night

Guest favorite

Home in Belleville

4.92 out of 5 average rating, 104 reviews

Whitestone Place: gorgeous, historic, updated home

3 bedroom home in the heart of historic Highland neighborhood in Belleville. Less than one mile from downtown historic Main Street, a quaint city area with charming shops and restaurants. Indoor fireplace, patio area with fire pit, and outdoor dining area. Chess and backgammon table in living room. 5 miles from Eckert’s Farm and other farms and orchards. 25 min drive to St. Louis city. Close proximity to Belleville metro link station, public transport to downtown St. Louis city life!

Feb 21 – 28

G$27,422 GYD per night

Guest favorite

Home in St. Louis

4.92 out of 5 average rating, 228 reviews

Cozy Curio in Benton Park

Located in the heart of Benton Park, this home is a spacious 2 story home full of curiosities. The intimate sleeping quarters are perfect for a couple or a couple friends sleeping separately. You'll be walking distance the best local bars, restaurants, cafes, the famous Anheuser Busch Brewery. It's also convenient to Busch Stadium and downtown. Please note; this is an historic home and some original details include steeper stairs to get upstairs to the full bathroom and sleeping areas.

May 12 – 17

G$27,685 GYD per night

Guest favorite

Home in St. Louis

4.94 out of 5 average rating, 456 reviews

Little Red House, Entire House in Tower Grove East

This 2 Bedroom 1 Bath home is centrally located in Tower Grove East, 5 minutes from St. Louis University, 8 minutes from Grand Center and just a few short blocks from hip South Grand and Tower Grove. It is the entire house, no neighbors to bother you. The block is quiet and the neighbors are friendly but please note this house is located in an urban area. If you are uncomfortable around people of mixed races and socioeconomic backgrounds please do not not book my place.

Sep 12 – 19

G$21,114 GYD per night

Superhost

Home in St. Louis

4.83 out of 5 average rating, 310 reviews

The Soulard Cottage | There Is Only One

Built in 1894, this historic, free-standing Cottage is a staple in Soulard. The Soulard Cottage is steps away from McGurks, Dukes, Mollys and all of Soulard's hottest spots! Not to mention, less than a 8 minute Uber to The Arch, Busch Stadium (Cardinals), Enterprise Center (Blues), the City Museum, The Aquarium and so much more! Here for business? Perfect! Here for a game? Perfect! This cottage will give you a truly unique experience while you explore St. Louis.

Nov 9 – 16

G$20,065 GYD per night

Guest favorite

Home in Belleville

4.99 out of 5 average rating, 146 reviews

The Pool House 1-Bedroom Home with Hot Tub & Pool

Soak in the hot tub or relax poolside at The Pool House! Its rural setting is perfect for a relaxing stay, romantic getaway, business trip or spending time with your family. Enjoy a full kitchen, electric fireplace and spacious bedroom. No pets allowed. No smoking allowed. No photo shoots are allowed. We do not have a TV, but do have wifi. **Military discount is available. Please message us first by clicking "Contact host".

Jul 17 – 24

G$28,261 GYD per night