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Vacation rentals in Santa Maria

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Maria

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Cottage in Los Fresnos

4.94 out of 5 average rating, 127 reviews

The Red Door Cottage

This 2 bedroom cozy cottage is located in Los Fresnos,TX. It's perfect for individuals,couples and small families. It can comfortably accommodate 4 ppl. We are conveniently located between South Padre Island,Brownsville,Harlingen and to all four international bridge crossings from Los Indios to Brownsville.For the enjoyment of all birdwatchers we are located in the middle of 3 major wildlife refugees. One being Laguna Atascosa National Wildlife Refuge. We're also 6miles away from windmill farm.

Apr 6 – 13

G$17,284 GYD per night
Guest favorite

Guesthouse in Harlingen

5.0 out of 5 average rating, 34 reviews

Peaceful Country Getaway

This private, cozy guest house is next to our home and includes a bedroom, bathroom, full kitchen, and living room. It has a beautiful view of our 2.4 acre property. Feel free to look at our chickens and rooster (don’t touch the electric fence). Amenities include a queen size bed, WiFi, refrigerator, oven, microwave, coffee maker and much more. Valley Baptist Medical Center–12 minutes Valley International Airport-15 minutes Brownsville–30 minutes McAllen–35 minutes South Padre Island–50 minutes

May 27 – Jun 3

G$15,227 GYD per night
Guest favorite

Home in Mercedes

4.88 out of 5 average rating, 17 reviews

Peaceful retreat awaits you! Relax in luxury

Discover the charm of le Boho Chateau, your perfect escape nestled in the heart of the Queen City of Mercedes. Just a quick 3-minute drive from the RGV Premium Outlets and expressway! Venture just 10 minutes to Mexico or 45 minutes to the pristine shores of South Padre. Indulge in the luxury of the master bedroom, fully equipped office space for remote work, and a delightful pool table for leisure. Step outside to the patio, complete with a BBQ pit, ideal for entertaining under the Texas sky.

Apr 2 – 9

G$30,088 GYD per night

Popular amenities for Santa Maria vacation rentals

Other great vacation rentals in Santa Maria

Guest favorite

Place to stay in Harlingen

4.91 out of 5 average rating, 78 reviews

Little Oasis Casita, Bird Watching Paradise

Jul 4 – 11

G$23,072 GYD per night
Guest favorite

Apartment in Weslaco

4.94 out of 5 average rating, 85 reviews

Modern comfortable retreat in gated community!

Jun 10 – 17

G$20,352 GYD per night
Guest favorite

Home in Weslaco

4.95 out of 5 average rating, 22 reviews

Casa Nuova Weslaco Tx

Jun 1 – 8

G$28,869 GYD per night
Guest favorite

Home in Weslaco

4.97 out of 5 average rating, 72 reviews

Mid Valley Casita Delight

Sep 11 – 18

G$19,825 GYD per night
Guest favorite

Apartment in La Feria

4.91 out of 5 average rating, 33 reviews

Orange Grove Duplex: 2 Bedroom/1Bath/Kitchenette

Feb 15 – 22

G$18,412 GYD per night
Guest favorite

Guest suite in La Feria

4.91 out of 5 average rating, 35 reviews

The Oak Tree Studio

May 18 – 25

G$15,024 GYD per night
Guest favorite

Tiny home in Harlingen

5.0 out of 5 average rating, 27 reviews

Tiny Country Cabin Luxury Living

Feb 25 – Mar 4

G$24,585 GYD per night
Guest favorite

Home in Weslaco

4.95 out of 5 average rating, 87 reviews

Weslaco Home - Calm & quaint cozy retreat

Jun 24 – Jul 1

G$22,122 GYD per night
Guest favorite

Apartment in Weslaco

4.93 out of 5 average rating, 76 reviews

Modern Mid Valley 2Bd Apartment in Gated Community

Apr 7 – 14

G$20,085 GYD per night
Guest favorite

Guesthouse in Weslaco

4.83 out of 5 average rating, 24 reviews

Private Remodeled Guesthouse in Central RGV

Aug 5 – 12

G$13,001 GYD per night
Guest favorite

Cottage in Harlingen

5.0 out of 5 average rating, 21 reviews

Philoxenia - Love of Strangers

Apr 2 – 9

G$17,701 GYD per night
Guest favorite

Apartment in Weslaco

5.0 out of 5 average rating, 25 reviews

Modern and Quiet Getaway

Apr 8 – 15

G$21,511 GYD per night

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