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Vacation rentals in Santa Maria

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Maria

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
Condo in Mercedes
4.94 out of 5 average rating, 145 reviews

Quiet huge 4 bed condo 2 miles by the Outlets!

Centrally located in the Rio Grande Valley. This quiet 3 bedroom condominium is a shoppers paradise only two miles away from the Mercedes Outlets! Travel into the most tourist friendly border city in Mexico, the city of Progreso, only 10 miles away! Head to the beach at South Padre Island, about 50 miles away. Be mesmerized by Elon's Space X at Boca Chica Beach 67 miles away! Level 2 charging outlet (nema 14-50R) reserved for you, bring your own EV charger. Unlimited free parking on premises.

Top guest favorite
Guesthouse in San Benito
5 out of 5 average rating, 26 reviews

Cozy Countryside Cottage

Welcome to Bethel Ranch, a peaceful rural escape just a short drive from South Padre Island and Starbase. Surrounded by open skies and quiet countryside, this calm, stylish stay offers privacy, comfort, and a slower pace. Enjoy cozy amenities, thoughtful touches, and a relaxing atmosphere ideal for unwinding after beach days, rocket launches, or coastal exploring. A serene retreat designed to help you disconnect, recharge, and enjoy a refreshing getaway. Ideal for guests seeking peace and rest.

Top guest favorite
Home in Edinburg
4.99 out of 5 average rating, 105 reviews

The Serene Home

Welcome to our Serene Home, where tranquility meets luxury for the ultimate escape. Nestled in the heart of Edinburg, this vacation home is a haven for those seeking a peaceful and rejuvenating gateway. The design blends Japanese with elements of zen-inspired architecture, creating a harmonious space that fosters relaxation. Natural light floods through large windows, illuminating the open living spaces. Embrace the serenity, and create lasting memories in this peaceful vacation home.

Superhost
A shared outdoor pool area is surrounded by a wooden deck and is complemented by a cabana featuring a green wall and decorative signage. Potted plants are positioned near the edge of the pool, providing a refreshing touch to the space.
Condo in Mercedes
4.81 out of 5 average rating, 171 reviews

Cozy and cute condo 3-5 to outlets n Stockshow

This unique place has a style all its own. Enjoy your gateway in this fully stocked closed to everything! You will have access to a huge pool and an assigned private pergola with tv and fire pit! Condo is completely private with private entrance Backyard pool area is shared only with two other Airbnb units Perfectly located in the heart of the valley: 🛍 Just 3 minutes to the outlet mall 🌆 25 minutes to McAllen 🚗 15 minutes to Harlingen 🏖 50 minutes to South Padre Island

Top guest favorite
A single-story home featuring a brick façade and a manicured front yard. Two palm trees stand nearby, while a concrete driveway accommodates multiple vehicles. Windows are framed by greenery, creating a welcoming exterior view under a partly cloudy sky.
Home in Weslaco
4.94 out of 5 average rating, 154 reviews

My House

Mi Casa Tu Casa Weslaco Tx, a small city that has everything. Enjoy every moment in this home that is made especially for you!.. 16 Minutes to Progreso bridge (Progreso México) 16 Minutes to Donna bridge (México Rio bravo) 31 Minutes to Valley International Airport (Harlingen tx) 23 Minutes to Mcallen International Airport and Plaza Mall 13 Minutes to Rio grande Valley Premium Outlet 6 Min from 83 Hwy 1:12 Min to south Padre island via 1-2

Guest favorite
The outdoor pool is illuminated in vibrant blue, creating a serene atmosphere. Surrounding the pool, a covered pergola features soft lighting and comfortable seating. The setting is enhanced by palm trees in the background, contributing to a relaxing outdoor space.
Guesthouse in Harlingen
4.84 out of 5 average rating, 210 reviews

Harlingen Guesthouse with a Pool

This place is a guesthouse located at the outskirts of Harlingen Texas. Very peaceful being it is out of city limits but still very close to restaurants, shopping etc. Just a 4 minute drive. You will have access to the pool and outdoor furniture as well as a charcoal grill. It is also a 45 minute drive to South Padre Island and 35 minute drive to the big city of Mcallen, Tx. and 15 minutes away from the outlets in Mercedes Tx.

Top guest favorite
The kitchen showcases wooden cabinetry and modern appliances, including a stainless steel refrigerator and oven. A small table with two chairs is positioned near the entrance. The space features tile flooring with a tiered step leading to the living area.
Guesthouse in Harlingen
4.99 out of 5 average rating, 106 reviews

Peaceful Country Getaway

This private, cozy guest house is next to our home and includes a bedroom, bathroom, full kitchen, and living room. It has a beautiful view of our 2.4 acre property. Amenities include a queen size bed, WiFi, refrigerator, oven, microwave, coffee maker and much more. Valley Baptist Medical Center–12 minutes Valley International Airport-15 minutes Brownsville–30 minutes McAllen–35 minutes South Padre Island–50 minutes

Top guest favorite
Apartment in San Juan
4.96 out of 5 average rating, 180 reviews

Casa Rafael

Make yourself at home in this centrally located apartment and experience everything the area has to offer. It is conveniently positioned just off the expressway, allowing you to easily access the freeway. Enjoy your stay with a variety of nearby restaurants and a Walmart just a minute away. This apartment is located on the second floor and has everything you need to make your stay comfortable.

Top guest favorite
Home in Harlingen
4.99 out of 5 average rating, 95 reviews

Private Fenced Yard | Near Dining & Shopping

Welcome to Casa by CMC I Enjoy a spacious living room with reclining green sofa chairs, a relaxing patio, and backyard. Each bedroom includes a TV, plus a 1-car garage and washer/dryer for convenience. Located 5 minutes from restaurants, 10 minutes from the medical center, and a short drive to Weslaco, McAllen/Edinburg, Brownsville, and South Padre Island—your perfect home away from home.

Guest favorite
The kitchen features modern cabinetry and sleek stainless steel appliances, including a refrigerator and microwave. A granite countertop offers ample space for meal preparation, complemented by bar seating for four. Natural light fills the area through large windows, creating a bright and inviting atmosphere.
Apartment in Weslaco
4.92 out of 5 average rating, 136 reviews

Modern comfortable retreat in gated community!

Minutes away from the outlet mall, the Progreso International bridge & much more. Perfectly located in the mid valley so you can decide if you want a beach day or a shopping day!! We welcome long term guests, medical visits, corporate visits etc. We want you to feel as comfortable as possible while you stay with us! Enjoy the best AirBNB experience available!

Guest favorite
Apartment in Harlingen
4.93 out of 5 average rating, 106 reviews

Fresh, Modern + Convenient Apartment

Indulge in the serenity of this exceptional apartment nestled in Harlingen, one of the Rio Grande Valley’s burgeoning locales. Whether you’re seeking a relaxing vacation close to numerous amenities or traveling for business with convenience in mind, this impeccably clean home offers the perfect retreat for any purpose.

Guest favorite
Apartment in Weslaco
5 out of 5 average rating, 10 reviews

Executive Suite

Enjoy your private suite designed for comfort and productivity. Enjoy two full bathrooms, a private office for remote work, and a stylish open living space ideal for short or extended stays. Perfect for professionals seeking peace, privacy, and convenience. It's a four-minute drive to the expressway.

Popular amenities for Santa Maria vacation rentals

  1. Airbnb
  2. United States
  3. Texas
  4. Cameron County
  5. Santa Maria