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Vacation rentals in San Antonio

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in San Antonio

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
Apartment in San Antonio
4.94 out of 5 average rating, 77 reviews

Suite in San Antonio with Private Patio and Rooftop

Located in the charming San Antonio neighborhood in Cali. You'll be just a short walk from Bulevar del Río, Calle del Sabor, restaurants, cafes, museums, bars, salsa academies and supermarkets, and just 10 minutes from the Cali Zoo, Cristo Rey, the Botanical Garden and Gato de Tejada. It is a quiet space, ideal for a good night's sleep or remote work, and it has a bonus that is hard to find in this location: a private patio with an outdoor dining area, perfect for breakfast or dinner outdoors.

Guest favorite
Home in Cali
4.88 out of 5 average rating, 17 reviews

Luxury minimalist house w/private pool, save area

EL AIRBNB MAS COOL DE CALI. Escápate a un oasis privado en una de las zonas más exclusivas de Cali. Esta casa minimalista combina diseño moderno, privacidad absoluta y una experiencia pensada para desconectar o disfrutar con estilo. Relájate en tu piscina privada, comparte en la zona BBQ o disfruta de un espacio tranquilo con seguridad 24/7 A pocos minutos de Granada, San Antonio y los mejores restaurantes de la ciudad, pero lo suficientemente aislado para sentirte en un refugio exclusivo.

Guest favorite
A staircase with black metal steps leads upward, set against a backdrop of exposed brick wall. Natural light flows through large wooden windows with bars, illuminating a decorative plant in a woven basket and a glass bottle on the floor.
Apartment in San Antonio
4.91 out of 5 average rating, 76 reviews

Cozy+Unique Loft/Touch of Nature/High Speed WiFi

*BRAND NEW* rustic yet luxurious & modern loft located in San Antonio. Walking distance from Cali's best restaurants, top bars/night clubs! Centrally located in Cali's famous artistic & colonial neighborhood of San Antonio, this chic loft comes equipped with everything you need for a comfortable stay. Full kitchen, queen sized beds, workspace, AC, washer, Smart TV, & more! If you are looking for a true cultural urban experience, with all of the amenities & comfort, then this is your place.

Guest favorite
An inviting dining area features a large wooden table surrounded by six green chairs. Soft light from pendant lamps enhances the open layout, which connects to a cozy living space with a comfortable sectional sofa. Large windows provide ample natural light.
Apartment in El Peñol
4.92 out of 5 average rating, 77 reviews

Spacious & cool apartment in El Peñon

Discover the charm of Cali in this completely renovated apartment, located in the heart of the trendies neighborhood of Cali. Equipped with everything you need to feel at home, from a French press with Colombian coffee to modern appliances such as an airfryer and blender. Two big screen TVs with Netflix for entertainment, washing machine, iron and more, ensuring a comfortable stay. El Peñon is one of the most famous neighborhoods in Cali, with some of the best restaurants, bars and clubs!

Guest favorite
Apartment in El Peñol
5 out of 5 average rating, 22 reviews

El Peñón Gem | Prime Location with Private Jacuzzi

★ Prime Location with Private Jacuzzi ★ Welcome to your stylish escape in Cali's most vibrant neighborhood. This modern 2-bedroom apartment offers everything you need for a comfortable and memorable stay, including a private jacuzzi, king & queen beds, A/C in every bedroom and dedicated parking, all just steps from top restaurants, cafes, and landmarks. Whether you're here to dance, explore or work remotely, this apartment brings you closer to everything that makes Cali unforgettable.

Guest favorite
A modern living area features a spacious white table paired with two black chairs. A light-colored sofa provides additional seating. Artistic wall decor complements the neutral color palette, while a large mirror enhances natural light and visual depth in the space.
Apartment in San Antonio
4.83 out of 5 average rating, 66 reviews

Luxury apartment in the Peñon

Luxury apartment located in the exclusive El Peñón neighborhood, the heart of the traditional hotel area of western Cali. Surrounded by a variety of restaurants, bars, nightclubs and cultural areas, close to emblematic sites such as the La Tertulia Museum, the Obelisk, the Cali Zoo, the Cerro de las Tres Cruces, the Gato del Río, the Bulevar del Río, San Antonio and Granada. Perfect for those looking for comfort, style and an unbeatable location to enjoy and explore the city.

Top guest favorite
Apartment in San Antonio
4.96 out of 5 average rating, 191 reviews

OM Studio Rooftop at San Antonio - Cali.

Om Studio Rooftop es un lugar para disfrutar de la tranquilidad y del ambiente que tiene. Deléitate con la brisa que baja de las montañas y el canto de los loros al atardecer, acompáñalo con una copa de vino, complácete con una taza de café al despertar, toma una ducha al aire libre y gózate el sol en la terraza en las mañanas. En las noches aprovecha todo lo que tiene el barrio San Antonio para darte. Un espacio único en el corazón de la sucursal del cielo.

Guest favorite
Apartment in San Antonio
4.9 out of 5 average rating, 113 reviews

402Studio with balcony in top area + AC and Netflix

Located in El Peñón, one of the safest and quietest neighborhoods in Cali. Steps from the 5-star Dann Carlton Hotel, surrounded by restaurants, bars, nightclubs, casino, museum and park. We have air conditioning, fast WiFi, TV with streaming apps and a free 24/7 laundry area. You can hear the passing of vehicles. Ideal for enjoying the city in comfort and an excellent location. In addition, we offer a clean, cozy environment with quick attention to any need.

Guest favorite
A spacious loft is displayed with an open layout featuring a modern kitchen that transitions into a cozy living area. Large windows provide a panoramic view of the city, while plants add a touch of greenery. The sleeping area is separated by stylish glass panels.
Apartment in Cali
4.94 out of 5 average rating, 102 reviews

H603 Private Jacuzzi | Balcony with Panoramic Views |

** EXCLUSIVE UNIT WITHOUT AIRBNB SERVICE FEES ** Located in the quiet Cristales neighborhood of Cali, this 48m² loft with a private Jacuzzi and an impressive view of Cali, perfect for up to 4 people, is fully equipped for your comfort. The building has amenities such as: coworking, gym, jacuzzis, picnic area, outdoor cinema, and more. Just minutes from Parque del Perro, it combines tranquility, modernity, and comfort in a perfect setting for your stay!

Top guest favorite
Apartment in San Antonio
4.98 out of 5 average rating, 40 reviews

Apartment close to everything, Peñon, Tina tourist area, A/C

✨ Moderno y acogedor apartamento en el exclusivo barrio el peñon Disfruta caminando el Boulevard del Río, Gato de Tejada, San Antonio, y relajate visitando los mejores restaurantes de Cali, bares y discotecas en la zona. ¡Te esperamos! Nota: Como varios edificios clásicos del Peñón, no tiene ascensor; el acceso es por escaleras. Es ideal para parejas y personas solas que quieren alojarse a pasos de los sitios más emblematicos y divertidos de cali.

Top guest favorite
A modern living space features a cozy seating area with a light blue chair and a gray sofa. A sleek kitchen with barstool seating is highlighted, complemented by contemporary pendant lighting and a stylish backsplash. Natural light fills the room, enhancing the vibrant decor.
Apartment in El Peñol
4.96 out of 5 average rating, 165 reviews

Penthouse Jacuzzi • El Peñón's Best Location

🌴 EXSTR Apartment • Villa del Peñon 401 🫧 Soak in your own open-air jacuzzi on a private terrace in one of Cali’s best locations. This 2-bedroom, 2.5-bath penthouse is perfect for couples, friends, or remote workers. Enjoy A/C, fast Wi-Fi, SmartTVs, a full kitchen, and fresh linens every 4 days. Walk to top restaurants, bars, and San Antonio in minutes. A relaxing, high-comfort stay in the city’s most walkable, cultural neighborhood.

Guest favorite
Loft in Cali
5 out of 5 average rating, 6 reviews

La Sucursal: Studio apartment in the heart of Cali.

Casa Azucar ✨ La Sucursal is a modern and cozy studio apartment, designed to offer tranquility and comfort amidst the vibrant energy of Cali. Ideal for couples or travelers, it features an equipped kitchen, a private bathroom with hot water, Wi-Fi, a Smart TV, and air conditioning. Located on the 3rd floor, on Calle 5, diagonal to La Topa Tolondra, near San Antonio and Loma de la Cruz. Great for sightseeing and for remote work.

Popular amenities for San Antonio vacation rentals

  1. Airbnb
  2. Colombia
  3. Valle del Cauca
  4. Cali
  5. San Antonio