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Vacation rentals in Santa Fe de Antioquia

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Fe de Antioquia

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Tiny home in Medellín

4.99 out of 5 average rating, 335 reviews

Refugio San Felix. A Small Haven Close to Medellin

A small, charming, comfortable and cozy retreat in a calm and beautiful country setting overlooking a scenic and peaceful valley of pastoral landscapes, lots of birds, broad skies and panoramic views 1 hour from Medellín. A haven to forget about your life in the city. A perfect stay for couples or friends searching for rest or intimacy. It is also ideal for creators, digital nomads or mistics looking for inspiration and undisturbed solitude to pursue their arts, crafts and paths.

Aug 5 – 12

G$16,234 GYD per night
Superhost

Cottage in Santa Fé de Antioquia

4.81 out of 5 average rating, 108 reviews

Rest and tranquility in Santa Fe de Antioquia

If you are looking for rest on the nature side this is a great option. Our estate is just two kilometers from the village of Santa Fe of Antioquia, with an extremely easy arrival. The estate has everything you need for a pleasant stay, and the kitchen is fully equipped. In addition to this you can enjoy a large green area, where you can see wildlife The wet area is very spacious, it has a swimming pool for children and another one for adults and in the hammock you can take a nap

Aug 30 – Sep 6

G$34,191 GYD per night
Guest favorite

Home in Santa Fé de Antioquia

4.91 out of 5 average rating, 188 reviews

Exclusive Villa with private pool!

Exclusive house with Jacuzzi and private pool, (maximum 10 people), spacious, modern, luxury finishes and fully equipped for a very comfortable stay. A quiet place, ideal to relax, unwind and share unforgettable moments with family, as a couple, with friends. Located two blocks from the main park of Santa Fe de Antioquia, a magical place, of great historical and cultural wealth, its colonial architecture and its cobbled streets that it still preserves are national heritage.

Sep 14 – 21

G$41,309 GYD per night

Popular amenities for Santa Fe de Antioquia vacation rentals

Stay near Santa Fe de Antioquia's top sights

Principal Park Santa Fe, Santa Fe de12 locals recommend
Hotel Mariscal Robledo6 locals recommend
La Chinca, Santa Fe De Antioquia Park9 locals recommend
Transport terminal5 locals recommend
Sabor Español9 locals recommend
Restaurante Portón del Parque5 locals recommend

Other great vacation rentals in Santa Fe de Antioquia

Guest favorite

Apartment in Santa Fé de Antioquia

4.93 out of 5 average rating, 45 reviews

Vacation apartment with pool

Aug 19 – 26

G$12,968 GYD per night
Superhost

Home in Sopetrán

4.85 out of 5 average rating, 62 reviews

Casa Utopía - in Sopetran!

Mar 17 – 24

G$49,473 GYD per night
Guest favorite

Cottage in Antioquia

5.0 out of 5 average rating, 28 reviews

Villa Luxury in Santa fé de Antioquia(Casa Creta)

Oct 23 – 30

G$123,874 GYD per night
Guest favorite

Home in San Jerónimo

4.96 out of 5 average rating, 24 reviews

Luxurious Villa, Pool & Exclusive Amenities

Jul 4 – 11

G$36,403 GYD per night
Guest favorite

Apartment in Santa Fe de Antioquia

5.0 out of 5 average rating, 22 reviews

Apartasol Citadela Di Sole

Sep 26 – Oct 3

G$10,106 GYD per night
Guest favorite

Shipping container in Sopetrán

4.98 out of 5 average rating, 66 reviews

Busping cabin_sopetran adventure

Nov 1 – 8

G$23,714 GYD per night
Guest favorite

Place to stay in Sopetrán

4.94 out of 5 average rating, 51 reviews

Finca en Santa Fe de Antioquia (Casa Marvella)

Oct 25 – Nov 1

G$66,954 GYD per night
Guest favorite

Cottage in San Jerónimo

4.97 out of 5 average rating, 65 reviews

The best view of Loma Hermosa. The best view.

May 24 – 31

G$21,109 GYD per night
Guest favorite

Vacation home in Santa Fé de Antioquia

4.85 out of 5 average rating, 75 reviews

Luxurious holiday apartment in Santa Fe Ant with Jacuzzi

Jul 1 – 8

G$18,869 GYD per night
Guest favorite

Villa in Santa Fe de Antioquia

4.91 out of 5 average rating, 35 reviews

La Martheja Summer House, "Come rest"

Feb 2 – 9

G$60,234 GYD per night
Superhost

Villa in San Jerónimo

4.89 out of 5 average rating, 9 reviews

Beautiful Estate in San Jerónimo

Jul 6 – 13

G$91,756 GYD per night
Guest favorite

Apartment in Santa Fé de Antioquia

5.0 out of 5 average rating, 25 reviews

Casa Amelí, in the heart of Santa Fe!

Jun 3 – 10

G$15,112 GYD per night

Quick stats about vacation rentals in Santa Fe de Antioquia

Total rentals

360 properties

Rentals with a pool

260 properties have a pool

Pet-friendly rentals

180 properties allow pets

Family-friendly rentals

200 properties are a good fit for families

Total number of reviews

5K reviews

Nightly prices starting at

G$2,094 GYD before taxes and fees

Frequently Asked Questions

  • How is the weather in Santa Fe de Antioquia?

    Santa Fe de Antioquia has a tropical climate. The temperature is typically very warm year-round, ranging from 75°F to 95°F (24°C to 35°C). There is a significant amount of rainfall throughout the year, with the heaviest occurring from April to November.

  • What are some of the best things to do in Santa Fe de Antioquia?

    Visitors to Santa Fe de Antioquia can explore the well-preserved colonial architecture, visit the historic Puente de Occidente, and immerse themselves in the rich cultural heritage at the Museo de Arte Religioso. In addition, the town's cobbled streets and charming plazas invite leisurely strolls.

  • What is the best time of year to visit Santa Fe de Antioquia?

    Santa Fe de Antioquia is often visited between December and January, when the town hosts its frequently suggested National Festival of the Trova. It's a celebration of traditional music and poetry, and a great time to experience the local culture.

  • What are the best places to stay in Santa Fe de Antioquia?

    Visitors often choose to stay in the historic center of town, where many of Santa Fe de Antioquia's attractions are located. The areas around the Puente de Occidente and the Plaza Major are also popular, with a range of accommodations available.

  • What are the best places to visit in Santa Fe de Antioquia?

    Some often recommended places include the architectural marvel Puente de Occidente, the Cathedral Basilica of Santa Fe de Antioquia, and the Museo de Arte Religioso. The historic Plaza Major is a lively spot to experience the local culture.

  • What are some hiking trails in Santa Fe de Antioquia?

    Santa Fe de Antioquia is not particularly known for its hiking trails. However, the surrounding Antioquia region has several trails to explore, such as the Cerro Quitasol trail or the Anorí Ecological Trail, both showcasing Colombia's diverse flora and fauna.

  • What are some family activities to do in Santa Fe de Antioquia?

    Families can enjoy exploring the historic Juan del Corral Museum, taking a dip in the natural pools at Santafé Eco Park, or engaging in a fun-filled day at Comfama Tutucán Park which has an array of recreational activities for all ages.

  • What are some of the best day trip ideas in Santa Fe de Antioquia?

    A day trip to the nearby city of Medellín, about 58 miles (93 km) away, is often recommended. The city is known for its vibrant culture, modern architecture, and lush parks. Alternatively, visitors can explore the surrounding countryside and its traditional coffee farms.

  • Are there vacation rentals with a dedicated workspace in Santa Fe de Antioquia?

    Yes! Work meets play with ease at over 170 vacation rentals in Santa Fe de Antioquia featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Do condo rentals in Santa Fe de Antioquia have a kitchen?

    Absolutely! We offer over 20 condo rentals with a kitchen in Santa Fe de Antioquia. Enjoy a tailored experience with all the comforts you desire.

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