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Vacation rentals in Santa Clara

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Top-rated vacation rentals in Santa Clara

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Home in Gamboa

4.86 out of 5 average rating, 87 reviews

BirdHouse@ Gamboa Panamá Canal

Explore the wonders of the Panama rainforest and return to our magical tropical home! This unique house and pool is a wonderful place to escape the hustle of Panama City, celebrate nature, and enjoy family and friends. Gamboa is a safe, quiet town embedded in the Soberania National Park; it is the entry point to Pipeline Road, some of the best birding in the world. Or take leave of the forest and watch manatee, while fishing for peacock bass in Gatun Lake or paddling kayaks up the Chagres River.

Nov 21 – 28

G$76,282 GYD per night

Guesthouse in Gamboa

4.95 out of 5 average rating, 56 reviews

Gamboa Toucan Apartment casa # 126

Welcome to Gamboa! Only 35 minutes from downtown Panama, Gamboa. Situated in Soberanía National Park and on the shores of the Panama Canal, is a Mecca for Birdwatchers and Nature enthusiasts! Watch the wildlife right from the backyard of your fully equipped apartment. Feel the magic songs of thousands of birds welcoming the twilight of sunrise and dusk in this century old community. Easily explore wildlife on trials through the surrounding old growth jungle and by boat on the Panama Canal.

Oct 24 – 31

G$18,159 GYD per night

Home in Costa Esmeralda

4.96 out of 5 average rating, 104 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sand! Come relax with the whole family at this piece of paradise. Majestic Sand is located in a private beach community in Costa Esmeralda, San Carlos District, Panama. It is located a few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, Santa Clara and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool with multiple hammocks with views of amazing palm trees.

Jun 2 – 9

G$39,123 GYD per night

Earthen home in El Cope, Penonome

4.91 out of 5 average rating, 145 reviews

Beautiful Eco House in Panama

We are very pleased to offer our beautiful, modern, comfortable house designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and escape daily stress. It is in a beautiful part of Panama near a cloud forest national park. The house sits in 17 acres of forest and has 2 rivers for swimming. The house is very open allowing full enjoyment of nature. There are amazing hiking opportunities in the mountains with waterfalls and visits to local communities.

Jul 16 – 23

G$44,345 GYD per night

Home in Taboga Island

4.96 out of 5 average rating, 140 reviews

Casa Rosie - Taboga dream home

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Jul 14 – 21

G$50,604 GYD per night

Home in Las Colinas de Caceres de Arraijan

4.98 out of 5 average rating, 196 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Aug 30 – Sep 6

G$65,555 GYD per night

Guest suite in Gamboa

4.95 out of 5 average rating, 77 reviews

Beautiful annex in the middle of Gamboa Rainforest

Enjoy nature without leaving home in this historic town located in Parque Soberania and on the shores of the Panama Canal. Just 40 minutes from the stressful capital, you can relax walking, bird watching in Pipeline, kayaking, fishing on the Chagres River, on the island of monkeys, visiting an indigenous town or watching sloths. Also bike lovers will find their place. At night, take a relaxing bath and sleep peacefully.

Feb 9 – 16

G$15,149 GYD per night

Home in Vista Mar Golf, Beach & Marina

4.88 out of 5 average rating, 224 reviews

Luxurious Beach House - Private Pool Golf & Marina

Vista Mar Golf, Beach & Marina is a gated community with private security, with direct access to a state of the art golf course designed by J. Michael Poellot. It also has marina, heliport, tennis courts, direct private beach access, bars and restaurants. The house comes with an outdoor private pool & hot tub, also a amazing private outdoor kitchen, and an amazing sea view with spectacular sunrises and sunsets.

Nov 21 – 28

G$155,996 GYD per night

Loft in Panamá

4.94 out of 5 average rating, 52 reviews

Canal Loft

Apartment on 1st floor, ideal for couples who love good taste, tranquility and comfort. Nearby to the apartment there are trails to the Panama Canal, hills and jungle. Apartment on the 1st Floor, ideal for couples who love good taste, tranquility and comfort. Near the apartment there are trails to the Panama Canal, hills and jungle.

Apr 22 – 29

G$13,714 GYD per night

Vacation home in Arraiján

4.8 out of 5 average rating, 45 reviews

Apartment In Club De Playa, with Pool and BBQ

Relax with the whole family or friends in this quiet place to stay and spend beautiful days at the pool, beach, breeze and sea. Enjoy a beautiful landscape surrounded by mountains, walks on the beach sand, lake trails, enjoy a lakefront barbecue, playground or a waterfront barbecue on beautiful ranches.

Nov 22 – 29

G$15,718 GYD per night

Townhouse in Panama

4.94 out of 5 average rating, 127 reviews

Unique Historic House in Casco

Hip five bedroom house in the heart of Casco Antiguo. Designed by world renowned restoration architect; this house is a perfect spot for exploring Panama's wonders. Ideal for families wanting to spend some time around the vibrant historic area.

Oct 6 – 13

G$134,510 GYD per night

Cabin in Chame

4.88 out of 5 average rating, 67 reviews

Las Nubes En Chica

Relax on this unique and quiet getaway just an hour and an half from the city. Every nook of this magical place was meticulously designed to provide perfect escape to couples seeking intimacy, serenity, and unforgettable moments together.

Jan 17 – 24

G$19,394 GYD per night

Vacation rentals for every style

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Popular amenities for Santa Clara vacation rentals

Free parking on premises

Air conditioning

Other great vacation rentals in Santa Clara

Chalet in Veracruz

4.89 out of 5 average rating, 92 reviews

A beachfront property very near to Panama city

Jul 5 – 12

G$13,450 GYD per night

Guesthouse in El Valle de Antón

5.0 out of 5 average rating, 29 reviews

Spacious Casita with Bamboo View

Jun 25 – Jul 2

G$18,560 GYD per night

Home in Panamá Oeste

4.97 out of 5 average rating, 63 reviews

AX8 beach house near the city!

Jan 29 – Feb 5

G$22,680 GYD per night

Cottage in Panamá

4.95 out of 5 average rating, 20 reviews

Modern House in Altos de Cerro Azul with 2 rooms

Jun 3 – 10

G$25,684 GYD per night

Home in Río Hato

4.95 out of 5 average rating, 75 reviews

Spectacular beachfront house in Buenaventura!

Oct 3 – 10

G$143,730 GYD per night

Home in San Carlos

4.93 out of 5 average rating, 86 reviews

Beach House-Ocean View Rooftop Jacuzzi & Pool

Jul 26 – Aug 2

G$58,030 GYD per night

Apartment in Panamá

5.0 out of 5 average rating, 59 reviews

Cozy n Comfy con balcón in the heart of Casco

Oct 24 – 31

G$24,131 GYD per night

Cottage in Altos del Maria

4.93 out of 5 average rating, 96 reviews

Cabin with Spectacular Mountain View

Dec 2 – 9

G$70,572 GYD per night

Destinations to explore