Panhandle vacation rentals

Book unique vacation rentals, houses, and more on Airbnb

Top-rated vacation rentals in Panhandle

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

Guest favorite

Barn in Amarillo

5.0 out of 5 average rating, 472 reviews

❤️Hidden Hideaway with a View⭐️Close to I-40/City

Beautiful, serene, quiet & private barn apartment (built in 2021) with country views of the Texas sunrise & sunset from the patio. Secure & Safe!! Located away from all the hotels! Farmhouse look/feel. Great WiFi, abundant driveway parking (oversized parking available) and a wraparound corner patio. Close to I-40 (3 miles), yet far enough away that it doesn't feel like you are in the middle of nowhere. Less than 10 minutes from Amarillo where all the amenities of “city life” are available.

Apr 24 – May 1

G$22,113 GYD per night
Guest favorite

Home in Amarillo

4.96 out of 5 average rating, 251 reviews

Cozy 2 bedroom German Cottage.

Enjoy this cozy, unique, and tranquil getaway. It’s 575 sqft/ 1 1/2 blocks from Route 66. Sits back from the street at the end of a long, double wide, steep, driveway. There’s trees on the property. One bedroom has a queen size bed and the other a twin. Enjoy the sunset on the back deck. A 50 inch smart tv is in the living room. Make your coffee or tea and enjoy the can of cinnamon rolls in the refrigerator ready to bake. Stroll down Route 66, with its many antique shops, restaurants, and bars.

Jan 31 – Feb 7

G$14,804 GYD per night
Guest favorite

Guesthouse in Amarillo

4.98 out of 5 average rating, 774 reviews

Private & Relaxing Guest House off I-40 & I-27

This AirBnB is a detached private guest house in the historic neighborhood locally known as Wolflin. If you are just swinging through town for the night, our central location just off of Interstate 40 and Interstate 27 will get you in and out with ease. And if you’re planning on staying a little bit longer, you will feel right at home with amenities such as your own fully equipped kitchen and private laundry room. So take the opportunity to stay in this newly renovated guest house and enjoy!

Feb 25 – Mar 4

G$15,065 GYD per night

Popular amenities for Panhandle vacation rentals

Other great vacation rentals in Panhandle

Guest favorite

Home in Amarillo

4.97 out of 5 average rating, 263 reviews

Modern Charm - Hot Tub & Free Tesla Charging!

Aug 3 – 10

G$32,655 GYD per night
Guest favorite

Guesthouse in Amarillo

4.99 out of 5 average rating, 157 reviews

Nifty Nest Oasis / Impeccable Studio + Garden

Aug 2 – 9

G$16,163 GYD per night
Guest favorite

Home in Amarillo

4.97 out of 5 average rating, 408 reviews

Olsen Oasis with Tesla Charger

Oct 29 – Nov 5

G$30,207 GYD per night
Guest favorite

Home in Amarillo

4.98 out of 5 average rating, 533 reviews

Castle House

Sep 11 – 18

G$26,636 GYD per night
Guest favorite

Guesthouse in Amarillo

4.94 out of 5 average rating, 272 reviews

The Guest House: Quiet Country Living, City Nearby

Sep 17 – 24

G$25,844 GYD per night
Guest favorite

Home in Amarillo

4.91 out of 5 average rating, 323 reviews

Adversity Home, Located right off I-40 & Airport

Feb 8 – 15

G$26,949 GYD per night
Guest favorite

Home in AMARILLO

4.89 out of 5 average rating, 322 reviews

West Hills House on the Hill

Sep 2 – 9

G$19,309 GYD per night
Guest favorite

Home in Amarillo

4.95 out of 5 average rating, 170 reviews

The Pristine House

Aug 5 – 12

G$19,149 GYD per night
Superhost

Home in Amarillo

4.89 out of 5 average rating, 210 reviews

⭐ Elegant & Spacious 3BD/2BA ⭐ Near I-40

Aug 22 – 29

G$25,312 GYD per night
Guest favorite

Home in Amarillo

4.91 out of 5 average rating, 339 reviews

Hillside terrace estates. 4 bedroom 2 bath

Aug 21 – 28

G$26,987 GYD per night
Guest favorite

Guest suite in Amarillo

4.96 out of 5 average rating, 898 reviews

This suite is a clean, safe, private place to stay

Aug 29 – Sep 5

G$23,656 GYD per night
Guest favorite

Home in Amarillo

4.99 out of 5 average rating, 504 reviews

Go Green

Jun 1 – 8

G$20,420 GYD per night

Other great vacation rentals in Panhandle

Guest favorite

Home in Amarillo

4.99 out of 5 average rating, 230 reviews

Modern Retreat at Oakdale close to I-40 & airport

Feb 21 – 28

G$23,266 GYD per night
Guest favorite

Apartment in Amarillo

4.86 out of 5 average rating, 1177 reviews

Texas Space

Oct 27 – Nov 3

G$13,142 GYD per night
Guest favorite

Train in Canyon

5.0 out of 5 average rating, 210 reviews

El Capitan Boxcar Casita-Palo Duro Canyon/WTAMU

Aug 21 – 28

G$29,222 GYD per night
Guest favorite

Home in Amarillo

4.99 out of 5 average rating, 257 reviews

Relaxing Bungalow Efficiency with private parking.

Apr 22 – 29

G$18,863 GYD per night
Guest favorite

Home in Howardwick

4.94 out of 5 average rating, 366 reviews

The Pine Shed Lake Greenbelt, Golf Course

Sep 29 – Oct 6

G$26,061 GYD per night
Guest favorite

Guesthouse in Amarillo

4.97 out of 5 average rating, 572 reviews

Berachah House

Sep 5 – 12

G$12,250 GYD per night
Guest favorite

Townhouse in Amarillo

4.91 out of 5 average rating, 33 reviews

2 car attached garage/minutes to I27/I40/Downtown

Oct 29 – Nov 5

G$18,407 GYD per night
Guest favorite

Tiny home in Happy

4.99 out of 5 average rating, 80 reviews

Sunset Saloon Themed Stay - Wooden Hot Tub

May 11 – 18

G$29,698 GYD per night
Guest favorite

Home in Amarillo

5.0 out of 5 average rating, 96 reviews

Home Sweet Home 806

Feb 20 – 27

G$23,909 GYD per night
Guest favorite

Home in Amarillo

4.98 out of 5 average rating, 59 reviews

Private indoor mineral pool & spa retreat house

Sep 10 – 17

G$100,624 GYD per night
Guest favorite

Home in Amarillo

4.97 out of 5 average rating, 67 reviews

Amarillo Pool House+hottub

Oct 28 – Nov 4

G$41,380 GYD per night
Guest favorite

Home in Amarillo

5.0 out of 5 average rating, 60 reviews

Explore Palo Duro Canyon & rest here. Dog friendly

May 25 – Jun 1

G$29,162 GYD per night

Destinations to explore