Vacation rentals in Los Santos Province

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Los Santos Province

Guests agree: these stays are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Guesthouse in Pedasi

5.0 out of 5 average rating, 24 reviews

A Remote Paradise in nature - Ocean View

'Tres-Palmas' sea and nature at its best! A remote hideaway on the Pacific Coast of Panama, but yet close enough to nearby towns and entertainment, Tres Palmas is the perfect place for an invigorating holiday. It is more than just a place to stay, we offer our guests personalized attention through fully equipped facilities and services for your comfort and well being. We enjoy getting to know our guests, sharing life stories and greeting you with an authentic smile for an unforgettable stay.

Jun 2 – 9

G$29,269 GYD per night

Guest favorite

Vacation home in Chitré

4.97 out of 5 average rating, 34 reviews

CASA EdditA ° Cozy house in Chitre

° HOUSE EDDITA ° Fully equipped house for your enjoyment. Spacious, cool and cozy in one of the best located residential areas of Chitré, close to everything: supermarkets, casinos and bus terminal. If you are thinking of touring Azuero we suggest making a stop at Casa Eddita, getting to know the center of Chitré, its handicrafts, the cathedral and its variety of typical meals; from here you will be just 1:30 hr from the best beaches in Azuero in Pedasí (Playa Venao and Isla Iguana). Welcome!

May 27 – Jun 3

G$22,040 GYD per night

Guest favorite

Cabin in Cambutal

5.0 out of 5 average rating, 13 reviews

Charming Cabaña on the beach

If you're looking for a place to relax and experience the magic of Cambutal with its lush jungle and stunning beaches, look no further. Nestled amongst the trees and overlooking one of the best swimming bays around, this rustic wooden cabaña has everything you need to make your stay unforgettable. Wake up to the sounds of the ocean on your doorstep, spend your days swimming in the warm ocean, or try other exciting activities, such as horse riding, hiking, yoga, surfing, diving and snorkelling.

Jun 11 – 18

G$18,407 GYD per night

Guest favorite

Home in Pedasi

4.94 out of 5 average rating, 16 reviews

2/2 Private Oasis Pedasi's best location & rental!

You wont find a better rental in Pedasi! Every aspect of the unit is upgraded and designed as if it was your home! Private pool with sound system, private outdoor kitchen, generator, 2 identical master suites with king beds, extra blow up queen mattress. Private laundry. Minutes walk from CooCoo Crazy or Jungle, two of the best restaurants in town. The beach a small jaunt away. Toiletries & basics included Property is for sale and is also available for long term rent! Message for details

Oct 7 – 14

G$20,097 GYD per night

Superhost

Home in Pedasí

4.9 out of 5 average rating, 40 reviews

Pedasí :Andromeda Boroda 4-6 p. Beach, swimm. pool

In the park of Andromeda. The house is suitable for 4-6 people, there are two bedrooms, two bathrooms with hot and cold water and a sofa bed (1,87 x 1,13) in the living room; for 1 adult or 2 small childeren. The master bedroom has a king-size bed, the second has two single beds. The covered carport for for 2 cars; has a (standard outlet) charging for an electric car. Bedrooms and living room are equipped with air conditioning and wireless internet. Shared pool and beach club are a 5 min. walk.

Sep 18 – 25

G$29,035 GYD per night

Superhost

Home in Santo Domingo

4.8 out of 5 average rating, 5 reviews

3 bedroom 2 bath with pool & bonus rooms!

Enjoy a memorable visit when you stay in this unique house. This beach house is located at Uverito Beach, which is at your footsteps. Two floors of open spaces for relaxation and lounging to the sound of the ocean. The beach house is perfect for a romantic retreat, relaxing family getaway, or a base for exploring the Azuero Peninsula. Long-term rental plus electricity of 28 days or more are available. You will get cable TV, Wi-Fi internet, hot water showers, gardener, and pool maintenance.

Apr 21 – 28

G$10,629 GYD per night

Guest favorite

Home in Pedasí

4.94 out of 5 average rating, 111 reviews

3 min to Pedasi, 5 min to the Beach, Private Pool!

Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

Jul 11 – 18

G$24,052 GYD per night

Guest favorite

Tiny home in Playa Los Destiladeros

4.86 out of 5 average rating, 37 reviews

Casita Brisa del Mar

Casita Brisa del Mar ~ Welcome to this special space which we have poured our hearts, souls, hopes and dreams into creating. 2 minute walk from one of the most beautiful beaches in Panama. Pacific Ocean views from every room (except the bathroom). We are also a drive away from limitless adventures on the Azuero Peninsula. This is generally a quiet neighborhood. FULL DISCLOSURE, there is currently construction happening next door to this property. The lowered price reflects this.

Jun 17 – 24

G$18,886 GYD per night

Guest favorite

Home in Playa Venao

5.0 out of 5 average rating, 15 reviews

Casa Samambaia - sea view tropical paradise w pool

With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.

Sep 18 – 25

G$56,788 GYD per night

Guest favorite

Loft in Playa Venao

4.94 out of 5 average rating, 81 reviews

Cottage Marilyn

This amazing 2 floor casita overlooking Playa Venao offers stunning views of the ocean and the surrounding hills. Enjoy refreshments by the infinity pool while watching the sun set over the bay... See when the waves are pumping right from your door step, whales macaus, monkeys... Dining, and nightlife on the beach are minutes away. This one bedroom casita also offers a sleeper sofa in living area for 1-2 guests, full kitchen, ac, cable TV, Wifi.

Aug 9 – 16

G$27,182 GYD per night

Guest favorite

Guesthouse in La Enea

4.95 out of 5 average rating, 41 reviews

Villa de Los Abuelos in Guararé

Get out of the capital city and come and enjoy Panamanian folklore in a rustic yet cozy space with an autochthonous experience. Lounge in the pool or lounge in a hammock, breathe fresh air, close to the ocean, surrounded by wide, natural gardens for a good walk. Close to the Port of Guararé where you will enjoy the best seafood and drinks or enjoy the heart of the best folklore event highlighting the traditions and the best Panamanian polleras.

Aug 13 – 20

G$18,652 GYD per night

Guest favorite

Home in Playa Venao

4.9 out of 5 average rating, 115 reviews

Beautiful Home Directly on Playa Venao Sleeps 8-10

This is our personal home and we take good care to make sure you thoroughly enjoy your stay! This home is located on the best surfing beach in the entire country. Walk out of your back door onto the sandy beach filled with wildlife and the best beach break for beginners to pros. This home offers luxury accommodations. This home is for families and respectful renters only. We do not accept groups who want to use the home to party.

Aug 2 – 9

G$111,673 GYD per night