Vacation rentals in La Mesilla

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Top-rated vacation rentals in La Mesilla

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Guesthouse in Velarde

4.95 out of 5 average rating, 287 reviews

Casita del Bosque

Enjoy the quiet of an old adobe casita in a traditional Northern New Mexico village, only a stone’s throw away from a multitude of attractions and activities. Explore our beautiful canyons, rivers, mountains and unique communities in every direction from Lyden. Experience modern-day Pueblo communities, ancient petroglyph sites, scenic drives, National Monuments, hiking/biking trails, birding hotspots, Georgia O’Keefe’s home, mineral springs and local restaurants. More in “Show Host’s Guidebook”!

Sep 17 – 24

G$22,677 GYD per night
Guest favorite

Home in Santa Fe

4.94 out of 5 average rating, 110 reviews

Hacienda Cielo de Nambe, Premiere Getaway Location

Unwind in the privacy & beauty of a historic adobe that was lovingly renovated in 2017. Nambe is known for its graceful private homes & is 20 min north of Santa Fe, an easy drive. At the Hacienda, adventures are just out your front door: Bandelier, Nambe Falls, Abiquiu, the Pueblos, just to name a few. Ancient cottonwoods surround the adobe, and the night sky is filled with stars. Please visit & make yourself at home, & create some special memories of your own here in the Land of Enchantment.

Sep 3 – 10

G$24,296 GYD per night
Guest favorite

Home in Santa Fe

4.95 out of 5 average rating, 126 reviews

Casita De Nambe

Our cozy 1 bedroom, 1 bathroom home can accommodate 4 guests, and is perfect for an amazing adventure in beautiful Northern New Mexico. Casita De Nambe is located in the heart of Nambe and comes fully equipped for both long or short term stays. Guests are provided with a fully equipped kitchen, stove heater, washer, dryer, WIFI and a smart TV compatible with Netflix & Hulu. The patio is equipped with a grill and a fire pit for outdoor activities as well as a fully gated yard, perfect for pets!

Aug 21 – 28

G$23,346 GYD per night

Popular amenities for La Mesilla vacation rentals

Other great vacation rentals in La Mesilla

Guest favorite

Guesthouse in Abiquiu

4.97 out of 5 average rating, 172 reviews

Pedernal Casita at Abiquiu Lake

Dec 17 – 24

G$18,484 GYD per night
Guest favorite

Dome in El Prado

4.9 out of 5 average rating, 1057 reviews

Geodesic Earth Dome

Feb 1 – 8

G$18,128 GYD per night
Guest favorite

Guest suite in Los Alamos

4.94 out of 5 average rating, 289 reviews

Guest Room Suite Private Entrance & Bath

May 10 – 17

G$22,066 GYD per night
Guest favorite

Guesthouse in Santa Fe

4.91 out of 5 average rating, 203 reviews

Santa Fe Guest House Sunset Views Private Quiet

Apr 26 – May 3

G$26,887 GYD per night
Superhost

Home in Abiquiu

4.83 out of 5 average rating, 364 reviews

Raven House

Oct 24 – 31

G$23,902 GYD per night
Guest favorite

Home in Santa Fe

4.98 out of 5 average rating, 902 reviews

Beautiful One Bedroom Casita

Oct 30 – Nov 6

G$23,879 GYD per night
Guest favorite

Home in Dixon

4.93 out of 5 average rating, 179 reviews

Long House in the Heart of Dixon

Dec 4 – 11

G$20,971 GYD per night
Guest favorite

Apartment in Vadito

4.94 out of 5 average rating, 109 reviews

Farmhouse Casita

May 16 – 23

G$16,413 GYD per night
Guest favorite

Guesthouse in Dixon

4.92 out of 5 average rating, 450 reviews

Rivers Edge Guest House

Sep 13 – 20

G$30,451 GYD per night
Superhost

Guest suite in Abiquiu

4.93 out of 5 average rating, 322 reviews

Star Dance Lodge Moon Casita

Sep 21 – 28

G$24,515 GYD per night
Guest favorite

Home in Dixon

5.0 out of 5 average rating, 235 reviews

Stylish cottage in a beautiful canyon on the river

Mar 2 – 9

G$34,520 GYD per night
Guest favorite

Tiny home in Santa Fe

4.99 out of 5 average rating, 318 reviews

Private Casita w amazing views & fenced in garden

Feb 21 – 28

G$25,602 GYD per night

Destinations to explore