Vacation rentals in Isla Grande

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Isla Grande

Guests agree: these stays are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Home in Corregimiento de Isla Grande

4.96 out of 5 average rating, 83 reviews

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Dec 10 – 17

G$100,945 GYD per night

Guest favorite

Apartment in Panamá

5.0 out of 5 average rating, 60 reviews

Cozy n Comfy con balcón in the heart of Casco

Remodelado, cómodo y céntrico alojamiento en el corazón de Casco Viejo, pintoresco lugar declarado Patrimonio de la Humanidad por la UNESCO. Cerca de restaurantes, Bares, Impresionantes Iglesias y Museos. Podrás explorar la zona a pie, el apartamento esta completamente remodelado, un balcón espectacular, cocina full equipada, camas cómodas, te sentirás como en casa, rodeado de las famosas paredes de calicanto. -Amplia sala de estar-Smart tv -Cocina full equipada -1.5 baños -Balcón con vistas

Mar 22 – 29

G$26,405 GYD per night

Superhost

Condo in Colón

4.86 out of 5 average rating, 167 reviews

HIDDEN BEACH RESORT & MARINA

The project is located in the Republic of Panama, in the coastal zone of Costa Arriba in the Caribbean Sea. You can spend the day preparing your BBQ in an oceanfront Bohío or if you prefer to delight in the delights of the Kayuco Restaurant located in the Club House. The project features activities with and at no cost depending on season, consult the administration office or the owner of the apartment. It has a swimming pool, lagoon, water park, games for children, sports fields, 2 islands.

Jul 4 – 11

G$55,747 GYD per night

Guest favorite

Apartment in Juan Gallego

4.85 out of 5 average rating, 155 reviews

Pebos Reef, apt #1, Amazing location !

This spectacular beachfront property is ideally situated with an incredible view of neighboring islands, fishing friendly waters, and mesmerizing snorkeling spots for children and adults to enjoy. Monkey greetings from the jungle adjacent, octopus and colorful native fish inhabited waters, and lazy bear sloth sightings are all part of your daily experiences here at Pebos Reef! If you are lucky you will even see dolphins from the terrace ! A terrace on the sea is all you need.

Mar 7 – 14

G$40,909 GYD per night

Guest favorite

Villa in Portobelo

5.0 out of 5 average rating, 42 reviews

Entire Villa with pool in front of beach!

Beautiful spacious 4 bedroom villa right in front of the sea. Enjoy the swimming pool with your family, then take a dip into the sea only steps away. Very pet friendly! Take a boat trip for the day with a local certified tour guide from portobelo town. Every room has full AC, including the living room - but please be conscious of the environment when using ACs. Excellent WiFi ! Open Kitchen, with breakfast included. We can also arrange for lunch - fresh lobster!

Apr 9 – 16

G$51,363 GYD per night

Guest favorite

Loft in Panamá

4.92 out of 5 average rating, 177 reviews

Amazing Loft with the Best view of Casco viejo!

Hermoso loft ubicado en el centro de Casco Antiguo, la zona más turística de Panamá. Ven, disfruta y relájate en este impresionante loft, con una vista increíble de la Catedral de Panamá. Puedes visitar museos, bares, restaurantes e iglesias ubicados a tan solo unos cuantos metros de distancia. Beatiful Loft located in the center of Casco Antiguo, Panama´s most turistic location. Come, enjoy and relax at this amazing loft, with amazing view to Panama´s Cathedral.

Apr 11 – 18

G$23,617 GYD per night

Guest favorite

Home in Taboga Island

4.96 out of 5 average rating, 140 reviews

Casa Rosie - Taboga dream home

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Sep 18 – 25

G$50,505 GYD per night

Guest favorite

Home in Cacique

5.0 out of 5 average rating, 18 reviews

El Paraiso

We are happy to introduce you to a large beautiful house for rent between the village of Cacique and the village of José Pobre in the Portobelo National Park. Overlooking the Caribbean Sea, nestled in the jungle , this house has a unique character in the area . Its direct access to a small wild beach, with an exciting reef for snorkeling fans makes it a great place. Ideal for groups and families wishing to connect with nature .

Dec 12 – 19

G$59,584 GYD per night

Guest favorite

Villa in Cacique

5.0 out of 5 average rating, 23 reviews

CARA AL MAR Cacique

In the middle of the Parque National de Portobello (access only by 4x4), nestled at the top of the hill, between sky and sea, away from all eyes, at the first lodges, a small cozy love nest to rest and disconnect (as a couple or with friends), comfortable, bright (large and high windows), spacious, cool (central air conditioning), witness of a grandiose show... awaits you...!

Mar 3 – 10

G$79,226 GYD per night

Guest favorite

Cottage in Panamá

4.95 out of 5 average rating, 21 reviews

Modern House in Altos de Cerro Azul with 2 rooms

This stunning home offers an unparalleled combination of modern luxury and natural beauty, making it the perfect spot for those looking for a serene mountain getaway. Enjoy an open concept space that integrates seamlessly with the surrounding landscape. Air Conditioned Rooms Flexible check-in and check-out hours. Grill

May 7 – 14

G$27,546 GYD per night

Guest favorite

Townhouse in Panama

4.94 out of 5 average rating, 127 reviews

Unique Historic House in Casco

Hip five bedroom house in the heart of Casco Antiguo. Designed by world renowned restoration architect; this house is a perfect spot for exploring Panama's wonders. Ideal for families wanting to spend some time around the vibrant historic area.

Jul 4 – 11

G$134,371 GYD per night