
House vacation rentals in Panhandle
Find and book unique houses on Airbnb
Top-rated house rentals in Panhandle
Guests agree: these houses are highly rated for location, cleanliness, and more.

Right by Cadillac Ranch | Cool, Clean, Convenient!
✹ PRIME LOCATION –We are the closest Airbnb to Cadillac Ranch — just a 30-second drive on the same road. We are just off I-40 !!!Strict No Smoking Policy!! NOT ALLOWED!! ✹ 2 bedrooms w/ a KING SIZE BED Nightlights closets & Netflix TVs in each room ✹ Private 5-acre lot for peace & quiet ✹ Central heat & A/C + super fast WiFi ✹ 3 miles to Soncy Rd – top dining & shopping ✹ 6 miles to Cinergy – movies, arcade & more ✹ Proud neighbor of Loves Travel Stop – grab a snack, fuel up, an hit the road.

The Bunny Bungalow
Enjoy a relaxing getaway for two in our brand new bungalow. The studio design features everything you need in one convenient living space - a king bed with fresh white cotton bedding and luxe pillows, comfy chairs for enjoying the fireplace and TV, intimate dining area and a stylish kitchen. The bath features a double vanity, tub for two and modern shower. A full size laundry set is tucked near the back door. The back yard features a cedar pergola with hot tub, a seating area and gas BBQ grill.

Magnificent Home, Game-room, Close to Everything
This ideally located private home is located in one of the newer developments in southwest Amarillo. This modern, stylish home is a 2-min drive to the Loop & easy access to I-27—taking you to the downtown district, dining, Hodgetown & the Civic Center. Head South you’re just minutes from Canyon, WT A&M University & Palo Duro Canyon. Plenty to do are only minutes away. This convenient home is ideal whether passing through town or better for longer stays with amenities that feel like home.

The Longhorn Lodge
This awesome little house is just 10 minutes from most of Amarillo. This house is very clean and newly built in 2024. Our guests all agree this is such a relaxing place to stay. The house itself is a small 1 bedroom, with everything you'll need for your stay. Inside the house is very clean and comfortable but outside is my favorite part. Here you'll find some of the best front porch sittin' around and the sunsets are pretty awesome too! You'll have wide open spaces and plenty of privacy.

The Castle-Family Friendly-Spacious-Large Parking
Come and enjoy this gorgeous home!🏡 Great for 🚗TRAVELING groups, or 🧑🧑🧒🧒 LARGE families! Peaceful neighborhood, with ☕️COFFEE SHOP, ⛽️GAS STATION, and 🍗DINNING across the street! Easy access to I-27, and a short drive to I-40. 4 BEDROOMS, and 3 full BATHROOMS! Beautiful primary bedroom, restroom , and walk-in close. Great for getting ready! 🏋️♀️There is a home gym with cable machine, squat rack, bench, plates and dumbbells! Great outdoor area for hanging out and grilling.

Chateau Bliss: Stylish Stay w/ HOT TUB
Escape to this spacious 3-bed, 3-bath retreat in Canyon, TX, featuring 2 king beds and 1 queen bed, just minutes from Palo Duro Canyon & WT. In the evenings you can relax in the hot tub! *5 Mins to Downtown and WT *10 Mins to Palo Duro Canyon *10 Mins to Maxwell's Pumpkin Farm *20 Mins to Hodgetown Stadium *30 Mins to Cadillac Ranch + Big Texan + Wonderland *Work From Home At Your Desk With Fast Wifi *Fully Equipped Kitchen *Bonus Outdoor TV + Hot Tub *Self Check-in

The Cottage On Tyler
Keep it simple at our peaceful and centrally-located in the heart of historic Downtown Amarillo. Our spacious & newly renovated 3 bedroom cottage is within walking distance from favorite local restaurants, bars & coffee shops. Our enclosed back patio provides for a cozy back porch gathering among family & friends. We are pet friendly & love our furry friends!

Clean, Spacious, Pet Friendly, X2 Living room
Whether you're seeking adventure, relaxation, or simply a peaceful family recharging retreat this breathtaking home is the perfect place to escape the hustle and bustle of everyday life! Immersing yourself in the stunning beauty of Palo Duro Canyon, our luxurious amenities, and the beauty of having nature at your doorstep, it's a vacation you'll never forget.

Rustic Gorge | Best Views of Palo Duro Canyon
Rustic Gorge in Rustic Luxury Camp offers an unmatched experience with our six tiny luxury cabins, providing spectacular views and a unique stay right on the edge of the second largest canyon in the US. Each cabin is meticulously designed to blend seamlessly with the natural beauty of the surroundings while offering luxurious comfort.

1-800 We got the stay
Your family will be close to everything when you stay at this centrally-located place. 5 minutes from the Amarillo Civc Center & Downtown Amarillo. 10 minutes from Starlight Ranch. 2 minutes from trade winds airport. 15 minutes from Rick Husband International Airport. 3 miles off I40 and 2 miles off I27.

Park Place
The whole group, including well-behaved house-trained pets, will enjoy easy access to everything from this centrally located place located on a quaint neighborhood park in an historic neighborhood with brick streets. The Place is decorated with hand-painted artwork by the host.

Cozy Amarillo Abode
Completely remodeled cozy two-bedroom home! Located just off I-40 with easy access to dinning and shopping. Short drive to Amarillo's medical district or Downtown area. Equipped with all new kitchen appliances and has washer and dryer available. Has a great homey feel!
Popular amenities for Panhandle house rentals
House rentals with a pool

Resort home in Amarillo 4/3.5 w/ pool and hot tub

The Giving Canyon 2

Holyoke Haven

McKinley House Prime - Pool, Patio and Garage

Friends & Family Fresno House

The Giving Canyon 1
Weekly house rentals

Elegant, Two Living Rooms, I-40, Rt 66, & Downtown

Yellow Door | Close to I-40 | Private Bball Court

Emery’s Place - Game Room, 2 king beds, WT & PDC

Greener Pastures with large covered patio

Welcome to “Vista Verde”

Sleeps 16+ Arcade Game House Near Palo Duro

Whispering Pines Ranch

Skyhouse at Doves Rest Cabins
Private house rentals

Now Available! Casa Blanca: Industrial Home

The Grand View

Coops Deane home, 2bd 1bth, Dog friendly

Bobs Sleepy Hollow Home

Family-Pet-Friendly home with Fenced Yard

Home in great neighborhood

Beautiful Modern Full House

Wheeler's Country Home
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