
House vacation rentals in Panhandle
Find and book unique houses on Airbnb
Top-rated house rentals in Panhandle
Guests agree: these houses are highly rated for location, cleanliness, and more.

Right by Cadillac Ranch | Cool, Clean, Convenient!
✹ PRIME LOCATION –We are the closest Airbnb to Cadillac Ranch — just a 30-second drive on the same road. We are just off I-40 !!!Strict No Smoking Policy!! NOT ALLOWED!! ✹ 2 bedrooms w/ a KING SIZE BED Nightlights closets & Netflix TVs in each room ✹ Private 5-acre lot for peace & quiet ✹ Central heat & A/C + super fast WiFi ✹ 3 miles to Soncy Rd – top dining & shopping ✹ 6 miles to Cinergy – movies, arcade & more ✹ Proud neighbor of Loves Travel Stop – grab a snack, fuel up, an hit the road.

Castle House
Castle House is a unique newer home convenient to I-40 in an established quiet neighborhood. Circle drive in front, parking up to 3 cars. Home is updated. Each bedroom has it’s own on-suite with toiletries & hairdryers. Kitchen has granite counters and stainless steel appliances. Large dining table to gather around. Desk areas and a laundry room are available. We are "dog" friendly with fenced yard. Events by request only. Note: After two guest it is an extra $12 per guest each night.

The Bunny Bungalow
Enjoy a relaxing getaway for two in our brand new bungalow. The studio design features everything you need in one convenient living space - a king bed with fresh white cotton bedding and luxe pillows, comfy chairs for enjoying the fireplace and TV, intimate dining area and a stylish kitchen. The bath features a double vanity, tub for two and modern shower. A full size laundry set is tucked near the back door. The back yard features a cedar pergola with hot tub, a seating area and gas BBQ grill.

Texas Rustic⭐️⭐️⭐️⭐️⭐️Unit-B (I-40 & I-27)
The Texas Rustic fully furnished Unit-B Duplex with amenities and 2 bedrooms, 1 bath, Smart tv, Netflix, Wifi. Decorated with rustic and industrial design. BBQ patio sets backyard fenced for pets. Beautiful spacious stained concrete area parking for Airbnb guests. Easy access to I-27 and I-40 for shopping, restaurants "Route 66", Cadillac Ranch and world famous Big Texan Steak Ranch entertainment. Located about 20 minutes to Palo Duro Canyon State Park. HODGETOWN baseball. Welcome y'all!

The Longhorn Lodge
This awesome little house is just 10 minutes from most of Amarillo. This house is very clean and newly built in 2024. Our guests all agree this is such a relaxing place to stay. The house itself is a small 1 bedroom, with everything you'll need for your stay. Inside the house is very clean and comfortable but outside is my favorite part. Here you'll find some of the best front porch sittin' around and the sunsets are pretty awesome too! You'll have wide open spaces and plenty of privacy.

🌺 KiKi’s Kottage 2/BR 2/Bath Renovated 1920’s Gem
Our cottage has everything you need for a comfortable stay, whether a short stop over or to spend a while checking out everything Amarillo has to offer. We have completely renovated this 1920’s gem and brought back its original charm. Take a stroll or walk the dog in our historic neighborhood with two parks just steps away. We are centrally located and just minutes from I 40. Also close to downtown and so many great restaurants. We feel you will be right at home in our comfy Cottage.

The Castle-Family Friendly-Spacious-Large Parking
Come and enjoy this gorgeous home!🏡 Great for 🚗TRAVELING groups, or 🧑🧑🧒🧒 LARGE families! Peaceful neighborhood, with ☕️COFFEE SHOP, ⛽️GAS STATION, and 🍗DINNING across the street! Easy access to I-27, and a short drive to I-40. 4 BEDROOMS, and 3 full BATHROOMS! Beautiful primary bedroom, restroom , and walk-in close. Great for getting ready! 🏋️♀️There is a home gym with cable machine, squat rack, bench, plates and dumbbells! Great outdoor area for hanging out and grilling.

Country Club Cutie (Washer/Dryer.) No pets!
Cozy 3 bedroom house with beautiful but creaky, hardwood floors with easy access to Rails to Trails path that is perfect for walking, riding bikes, or watching beautiful West Texas sunsets. Large backyard. Washer and dryer in property. Quiet street . Full size fridge and central heat and air. Ask me about our supportive running community. Easy access to I40 to see the Cadillac ranch and beautiful Palo Duro Canyon. Please consider my request for no pets and no smoking in my home.

Explore Palo Duro Canyon & rest here.
Booking party must be staying Locals on approval only with photo ID Hike bike the canyon and relax during your stay in this spacious 1 bedroom with kitchen, washer/ dryer, WiFi, smart TV log into your app of choice, loft has 2 futons suitable for kids / teens. Beautiful yard with 2 covered patios. Secure area in fenced backyard to store all your gear! Not suitable for infants. Same day requests not available.

The Guest House
A simple, spacious guest house situated on the outskirts of southwest Amarillo offers the tranquility of the countryside and stunning sunsets. Despite its serene location, it's just a 15-minute drive to Downtown Amarillo or Canyon, with plenty of entertainment and shopping options within a 10-minute radius. Medical district is a quick 12 minute drive. Additionally, it is pet-friendly.

The Cozy Cactus
Hey Yall! Welcome To Amarillo! Relax & Unwind in our cheerful and modern 2 bedroom home. Located in the historic Old Amarillo Country Club District and right around the corner from the beautiful Sam Houston Park. It's the perfect location to walk your dog, and feel free to light up our bbq grill in our large backyard. Newly renovated with style & your comfort in mind!

The Yellowstone 1/2 MILE FROM I-40 Amarillo
DAIKIN DUCTLESS HEATING & COOLING SYSTEM, WASHER & DRYER, WIFI & CABLE Beautiful guest house with amazing Western Theme decor. Fully remodeled, 1 bedroom, 1 bath, living room, kitchen, dining area, 693 sq ft private guest house nestled in the heart of the historic Bivins neighborhood. Master bedroom with king bed. Living room has a day bed and a couch.
Popular amenities for Panhandle house rentals
House rentals with a pool

Private indoor mineral pool & spa retreat house

Private Pool + Park Across Street

McKinley House Prime - Pool, Patio and Garage

Parkside Retreat

Furnished Guest House

Resort home in Amarillo 4/3.5 w/ pool and hot tub

The Giving Canyon 2

Holyoke Haven
Weekly house rentals

18th Street Retreat

Yellow Door | Close to I-40 | Private Bball Court

The Crystal Dragonfly

Backyard Oasis Renovated 1923 4/2 w big porch

Farmhouse-Inspired Home in the Center of Amarillo!

Charming Amarillo Hideaway

Your Home Away from Home

Indoor Hot Tub, Free EV Charger!
Private house rentals

Grady's

Southern Comfort: Cozy Retreat- 4 beds

Getaway vacation home

Coops Deane home, 2bd 1bth, Dog friendly

A Quiet Country Escape

Prattwood House

Whispering Pines Ranch

Legacy Landing | 3 Bedroom Home with Cozy Touches
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