Vacation rentals in Lee County

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Top-rated vacation rentals in Lee County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
The historic home features blue siding and a wide front porch adorned with festive garlands. Nestled among bare trees, the property showcases multi-story architecture, with a well-kept yard, providing a welcoming entrance. A gravel pathway leads toward the entrance of the home.
Vacation home in Carthage
4.94 out of 5 average rating, 152 reviews

Grandma Ruby's Vintage Victorian Downstairs Suite

This historic home built in 1884 has been completely renovated with loving care by a granddaughter with fond memories of magical times at her grandparents' unique home. With ten foot ceilings and beautiful craftsmanship, this spacious downstairs unit provides a master suite with a king sized bed and a big screen TV, a large kitchen, a queen bedroom, access to a large private back yard and plenty of parking. All conveniently located to town attractions and just 5 minutes from the interstate.

Guest favorite
A tranquil sunset is reflected on the calm waters of the Mississippi River, showcasing vibrant hues of orange and purple. The silhouette of trees is visible on the horizon, and the shoreline is lined with gentle vegetation.
Cottage in Dallas City
4.82 out of 5 average rating, 102 reviews

The River Cottage on the Mississippi

Enjoy the Great Outdoors in this freshly renovated 3 bedroom, 1.5 bathroom cottage right on the Mississippi River. Hunting, fishing, boating, outdoor games & campfires, bird watching or just plain R&R-this place has it all. City park in walking distance offers picnic shelters, sand volleyball & playgrounds. Public boat ramp down the road or fish right from the shoreline. Dallas City is well known for duck and deer hunting. Great for a guys weekend, girls retreat or just plain family fun!

Guest favorite
A charming green house stands surrounded by trees, featuring a sloped roof and an inviting orange door. A wooden deck extends from the front, with a rustic stone pathway leading up to the entrance. Stacked logs are arranged neatly in front.
Home in Nauvoo
4.96 out of 5 average rating, 47 reviews

Entire House - Horton Treehouse

Escape to a one-of-a-kind retreat nestled high in the trees — where comfort meets adventure & every window frames a postcard-worthy view of the Mississippi River. The home offers a magical experience. Inside, you’ll find a warm and inviting living space, a private Master Bedroom designed for rest and relaxation, and a spacious bathroom. The circular dining area & well-equipped kitchenette add charm & function, while the large outdoor deck is perfect for sipping coffee or stargazing at night.

Top guest favorite
The exterior of a charming white house with a gray metal roof is shown, framed by a small tree and well-maintained lawn. The front porch features black shutters, and a welcoming entrance is visible. A spacious yard leads to a fenced area at the back.
Home in Fort Madison
4.91 out of 5 average rating, 77 reviews

Luxury on 21st

Take a break and unwind at this peaceful oasis. This 1 bedroom home has been recently refreshed with new carpet, paint, light fixtures, and more. Spacious living area with room for a blow up mattress. Bathroom Amenities include your basic linens and a hairdryer. The kitchen includes basic cookware for you to use during your stay as well as. The washer & dryer are available for use. Please help yourself to the game cabinet for activities. Fenced in backyard with a small patio area.

Guest favorite
The cozy living area features a dark sofa positioned against a textured wall. A rustic wooden coffee table is centered on a patterned rug. Vintage nautical decor is displayed, including a ship's wheel and various framed art pieces. Soft lighting creates a warm ambiance.
Treehouse in Nauvoo
4.96 out of 5 average rating, 182 reviews

Captains Quarters Treehouse

An off the grid whimsical gem in the Ten Acre Treehouse forest! "The Captains Quarters". This is the 2nd treehouse in rural Nauvoo. A lot of the same touches found in "The Whitetail". The first treehouse here, you will find in this nautical inspired creation. This treehouse is a full 2 story, 400 sq foot, and features second story bedroom, sleeper sofa on the first floor, small kitchen area with refrigerator/freezer, microwave, coffee maker, plates, silverware, cups and a sink!

Guest favorite
A spacious living area features a large leather sectional sofa, inviting relaxation. A wooden dining table with chairs is visible in the background, surrounded by shelves filled with books. Light enters through glass doors, enhancing the comfortable ambiance of the space.
Guest suite in Keokuk
4.96 out of 5 average rating, 526 reviews

Tree of Life River Retreat

Located 1½ miles north of Keokuk, nestled on a bluff overlooking the Mississippi River, the Tree of Life River retreat is located in a cozy, private, walk-out lower level (with hosts living above). There's a private bedroom with a queen bed and another sleeping area with four twin beds, perfect for one person or a family. Relax, enjoy nature, and take advantage of our large backyard. We are located approximately 18 miles from downtown Nauvoo via the bridge in Keokuk.

Top guest favorite
A single-story residence features a light exterior with a symmetrical layout. A covered entryway leads to large windows that allow natural light. A driveway extends toward a spacious two-car garage, surrounded by well-maintained grass and landscaped plants.
Home in Carthage
4.93 out of 5 average rating, 184 reviews

Nice 2 bedroom home w/attached garage & deck.

Nearby attractions in Carthage include historic Carthage Jail & Kibbe Museum, historical Carthage courthouse, public swimming pool & golf course, several public parks & library, shopping, restaurants, and the Legacy Theater. Many recreational activities & special events year round. Located just minutes from the interstate. 16 miles from Nauvoo, IL. 15 miles from Keokuk, IA. 27 miles from Macomb, IL. 43 miles from Quincy, IL. 59 miles from Hannibal, MO.

Top guest favorite
A living room features a leather sofa, two vintage armchairs, and a round ottoman, creating a cozy seating arrangement. Natural light enters through large windows framed with sheer curtains. Dark wooden flooring contrasts with the light-colored walls and decorative art pieces are displayed throughout.
Home in Burlington
4.9 out of 5 average rating, 244 reviews

The Fleetwood Bungalow with Dreamy Porch

Welcome to The Fleetwood Inn! A charming, cozy one-bedroom bungalow in the heart of Burlington, Iowa. Right between our bustling business district and our nostalgic downtown, this little house has vast character. My favorite feature is all the original built-ins and beams. You will love the Western American inspiration and vintage finds, modern touches throughout, and dreamy details in every corner. Just added a Saatva Organic mattress for extra comfort.

Guest favorite
An open living area is shown with wooden flooring, featuring a large granite countertop with seating. Two dark sofas are positioned around a light carpet, creating a casual gathering space. Wall art adds a touch of color to the neutral walls, and natural light enters through a window.
Apartment in West Point
4.97 out of 5 average rating, 34 reviews

Dr. Poepsel Building Airbnb

Second floor two Bedroom apartment located on the Southwest corner of the West Point City Square. Great location close to local bars, bowling alley, restaurants and grocery store. Appartment has outside deck great for viewing the annual West Point Sweet Corn Festival the second weekend of August. This appartment has a spacious kitchen and living room. Master bedroom has a king size bed, tv and walk-in closet. The spare bedroom has a closet and tv.

Top guest favorite
The kitchen features modern white cabinetry with black hardware and a marble countertop. A stainless steel refrigerator and oven are visible, along with a dark backsplash. An island with a sink and a black faucet provides additional prep space.
Loft in Fort Madison
4.95 out of 5 average rating, 209 reviews

Beautiful Riverview Studio- steps away from Depot

Enjoy an exclusive view of the River, the FM Train Depot and Old Fort Madison from this 2nd floor true-studio apt. No cleaning fee for repeat and 5 star guests! The space has modern décor and all of the comforts of home. Railfans will enjoy the trains and river fans will enjoy the unique east-west river movement. There will be train sounds! The space comfortably sleeps two adults in its queen size Murphy bed. Please reach out with any questions.

Top guest favorite
The front of the Sonora Town Hall Cottage features a white exterior with a welcoming entrance. A landscaped area filled with vibrant yellow flowers and greenery is seen in the foreground, while a scenic view of fields is visible in the background under a cloudy sunset.
Farm stay in Nauvoo
4.99 out of 5 average rating, 199 reviews

Nauvoo with a country view

We welcome guests to our 1880 Sonora Town Hall Cottage. This building once served as a voting poll for the Sonora Township. It is now a beautiful boutique cottage for overnight guests staying in the Nauvoo area. We are located on a working grain farm 6 miles southeast of Nauvoo. PLEASE NOTE: NO SMOKING or VAPING on the premises. We do have security cameras outside of the town hall building, which provide security and lighting for all guests.

Top guest favorite
A modern kitchen features white cabinetry and a large dining table surrounded by six chairs. Stainless steel appliances, including a refrigerator, add a contemporary touch. A ceiling fan hangs above, with sunlight filtering through the nearby windows, adorned with light curtains.
Religious building in Nauvoo
4.96 out of 5 average rating, 112 reviews

Nauvoo's Old Stone Church

Known as "The Old Stone Church," "The Legion Hall," "The Temple Stone Church," or "The Old Methodist Church," this building has a remarkable story to tell. Every group who has been in what is now Nauvoo, has played a part in its history. ​ It has now been thoroughly renovated, and serves as an elegant vacation home for those visiting Nauvoo, and looking for an historic experience, with all the modern luxuries.

Popular amenities for Lee County vacation rentals

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