House vacation rentals in Durham County

Find and book unique houses on Airbnb

Top-rated house rentals in Durham County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Durham

4.88 out of 5 average rating, 200 reviews

Woodland Retreat near Duke/Downtown Durham/Eno Riv

Relax in this quaint neighborhood home tucked away in the trees. With a spacious front porch and glass doors onto deck in private backyard, this open yet cozy cottage offers the best of both worlds. Located within 5 mins of Duke Regional and Eno River State Park, close to Duke University and Hospital as well as downtown Durham. Come relax and enjoy all Durham and the RTP has to offer. This private home has a first floor bedroom and full bath as well as two more bedrooms and a full bath upstairs.

Sep 27 – Oct 4

G$25,465 GYD per night

Guest favorite

Home in Durham

5.0 out of 5 average rating, 8 reviews

Comfy place, ideal location

Enjoy a comfortable stay in this beautiful, newly renovated home with plenty of privacy. It's also well located, close to the highways and minutes to Duke's campuses, Duke hospital, downtown and Ninth/Broad. Functional open floor plan provides plenty of space to cook, work and spend time with family and friends. Relax on the screened in back porch, grill on the back deck or sip a cup of coffee on the front porch. Each bedroom has it's own en suite bathroom and there's a half bath for guests.

Dec 22 – 29

G$21,781 GYD per night

Guest favorite

Home in Durham

4.97 out of 5 average rating, 35 reviews

A Home Get Away

Relax in this unique and cozy private cottage getaway just minutes from the heart of Durham. Enjoy the comforts of a newly & fully renovated adorable 2-bedroom, 1-bath house with a fully equipped kitchen that allows you to indulge in your culinary desires. Whether attending a local festival, the excitement of a college game, or simply taking in a play, no matter the reason, retreat to a cozy night stay adorned with luxurious linens & pillows, smart TVs, work surfaces, along with Wi-Fi access.

Jul 6 – 13

G$24,632 GYD per night

Guest favorite

Home in Durham

4.9 out of 5 average rating, 357 reviews

The Bird's Nest

This newly renovated lower level apartment is nestled in the peaceful Forest Hills neighborhood. Our space is in an ideal location to enjoy all that Durham has to offer and comes complete with everything you'll need to feel at home. Minutes from excellent restaurants, outdoor fun, and cultural entertainment. Enjoy an evening at DPAC, a Durham Bulls baseball game, an energizing game of tennis at Forest Hills park, or a relaxing stroll through Duke Gardens. All just minutes from our doorstep.

Oct 23 – 30

G$18,601 GYD per night

Guest favorite

Home in Bahama

4.86 out of 5 average rating, 236 reviews

Cozy & relaxing cottage on the lake *Dog Friendly*

Cozy Lake cottage on the Little River Lake. Come relax on the porch with your coffee in the mornings or take an afternoon nap on the hammock. Fish for a little in the afternoon or go down to the Little River Lake Facility and rent a canoe. It’s the perfect get away that is still close to town and wonderful restaurants. Up to two well behaved and vaccinated dogs are welcome on the property. Dog fee $75 for up to two dogs. Sorry, no cats due to allergies. Swimming is not allowed in the lake.

Oct 3 – 10

G$38,895 GYD per night

Guest favorite

Home in Durham

4.98 out of 5 average rating, 159 reviews

Stylish Digs @ Duke, Campus Bus & EV Charger

Live like a Blue Devil at our centrally located Duke duplex. Enjoy the convenience of the campus bus stop right outside your door, minutes from East and West Campus. Explore Durham's museums and restaurants. Our family and pet-friendly home features Little Waves coffee, retro bathroom, hotel-like bedrooms, and earth safe soaps. Charge your electric vehicle using our EV charger. Book now for a unique and comfortable stay, with a portion of the income supporting refugees through Airbnb.org.

Aug 18 – 25

G$37,263 GYD per night

Guest favorite

Home in Durham

4.93 out of 5 average rating, 131 reviews

Cozy home 2mi from DPAC & Duke Hospital!

Adorable dog friendly cottage in the heart of Walltown, one of the classic neighborhoods that drive Durham's popularity. One block from Duke East Campus, three blocks from the bars and cafes of 9th street, & a short Uber or Lyft to downtown or Duke hospital. The small cottage is full of charm and character with open kitchen and living area with granite counters, tiled kitchen and bath, and back screened porch. It offers Central heat and air, dishwasher, washer/dryer.

Aug 30 – Sep 6

G$32,976 GYD per night

Superhost

Home in Durham

4.87 out of 5 average rating, 143 reviews

CHARM & Convenience!! 3Br Cottage-Style Ranch

This home is located in the more DESIRABLE and 'not as congested' low crime area of Durham near Chapel Hill, on a half acre lot in the rural buffer zone! You're really convenient to Duke Hospital/Duke campus, and also just a very short drive to Chapel Hill! The backyard is BIG and completely fenced in for family games or just enjoying the birds, or your dog's exercise! Duke Forest trails and New Hope Creek are VERY nearby for a wonderful hike during your stay.

Jul 21 – 28

G$24,688 GYD per night

Guest favorite

Home in Durham

4.95 out of 5 average rating, 128 reviews

Cheerful 3 BR home in South Durham near everything

You'll be close to everything at this centrally-located South Durham home on a quiet cul de sac. Brand new flooring throughout the house! Dog friendly with a spacious fenced in back yard and screened in porch. The house is located one mile from the main highway and 10-20 minutes from Duke, UNC, Raleigh, RTP and more. You'll also be walking distance from a playground, dog park, grocery stores, restaurants, local coffee shop, and the Tobacco Trail.

Apr 12 – 19

G$29,131 GYD per night

Guest favorite

Home in Durham

4.89 out of 5 average rating, 271 reviews

Hyacinth House

Hyacinth House Newly remodeled house in the heart of a wonderful Durham neighborhood. 5 minutes to Duke University, 20 minutes to UNC Chapel Hill, 15 minutes to Research Triangle Park, 20 minutes to Raleigh-Durham Airport. Close to many shops and restaurants. Family friendly neighborhood, large fenced back yard. Screened porch. After each stay, the house is cleaned according to CDC recommendations.

Oct 2 – 9

G$37,879 GYD per night

Guest favorite

Home in Durham

4.95 out of 5 average rating, 317 reviews

★ XL Yard ★ Keyless Entry ★ Full Kitch ★ W/D

Leave your car at home! Nestled in the burgeoning Southside neighborhood, you’re a few minutes walk along the American Tobacco Trail to the heart of downtown- DPAC, American Tobacco Campus, and Five Points. Distance to major attractions: DPAC / American Tobacco District- .8 mile Duke University- 2.9 miles Duke Hospital- 3.1 miles

Jul 25 – Aug 1

G$23,575 GYD per night

Guest favorite

Home in Research Triangle Park

4.91 out of 5 average rating, 44 reviews

Peaceful Cottage, near Downtown

Kick back and relax in this calm and stylish place. Perhaps you need a Quiet environment with fast wifi to work remotely? This cozy cottage is just a few minutes from downtown Durham, Duke University/Hospital, RDU airport and the Research Triangle Park. Come stay with us!

Nov 6 – 13

G$18,768 GYD per night