Vacation rentals in Clayton County

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Top-rated vacation rentals in Clayton County

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Guest favorite

A quaint blue house is shown from the side, surrounded by lush green grass. A wooden fence partially outlines the property, with a few flowering plants positioned along the edge. Clear skies and sunlight illuminate the exterior, highlighting its welcoming presence.

Home in Prairie du Chien

4.98 out of 5 average rating, 172 reviews

Ohio Street Retreat- hot tub, massage chair, pool

After a fun day in The Driftless Area, come relax and unwind in Prairie du Chien. Beautifully decorated 2 bedroom home with a spacious kitchen, large island, dishwasher, washer/dryer & 5' walk in shower. We supply all cooking/baking items/utensils. High-speed internet with smart TVs in both bedrooms and living room. Outdoor pool (seasonal), hot tub and massage chair. We love dogs too, so we provide a dog run (there is a pet fee). For our fishermen- there is off street parking for your boats.

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Guest favorite

The exterior of a two-story apartment building features a covered balcony with patio furniture, accessible from the upper level. A pathway leads to the entrance, bordered by well-maintained landscaping and stone accents. Trees display a range of autumn colors in the background.

Loft in Marquette

4.92 out of 5 average rating, 48 reviews

Eagles Overlook

This charming one-bedroom apartment offers everything you need for a great getaway! Enjoy cozy furnishings and a private balcony with views of main street and a local winery. Beautiful in every season, this quaint river town invites you to return time and again. Discover the beauty of the Driftless Area, featuring the Mississippi River, Pikes Peak State Park, Effigy Mounds and Yellow River Forest. Plus, enjoy a variety of shopping, dining, and entertainment options, including a nearby casino!

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Guest favorite

The image shows a wooden staircase leading down from a covered porch, framed by railings. A pathway is visible at the bottom, covered with grass, and a grassy area extends beyond. A small shelter with a blue roof stands in the distance.

Home in Elkader

4.86 out of 5 average rating, 35 reviews

Small-town Charmer (please read- rural location)

Relax with the whole family at this peaceful place to stay. 3 bedrooms 2 bathrooms. Quiet area close to nature and scenic roads and parks. Nestled between Elkader and Strawberry Point. Close to Backbone State Park and Volga/Turkey Rivers. This is a rural property, not located in a town with any amenities. You must bring what you need or plan to travel 8 miles to Elkader (Dollar General, Wilkes Grocery, pit stop gas station)or strawberry point (Dollar General, Casey’s and Nadings gas stations)

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Guest favorite

The Victorian home features a charming architectural design with a turret and expansive wrap-around porch. Large windows are adorned with decorative trim and flower boxes, surrounded by neatly landscaped gardens and lush greenery.

Home in McGregor

4.94 out of 5 average rating, 238 reviews

McGregor Manor Victorian Getaway

Welcome to our beautiful Victorian home located in the quaint town of McGregor, Iowa. Our 2,800 sq. ft. home was built during McGregor's early years as a Mississippi River boom town. Attractions include antiquing, biking, fishing, hunting, hiking and boating! We're a short drive from Pike's Peak, Effigy Mounds and Prairie du Chien. All four bedrooms on the 2nd floor of the home include a private bath, providing comfort and privacy for each member of your group. Fully furnished and decorated.

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Top guest favorite

The newly constructed house features a pitched roof and a wraparound porch, surrounded by a grassy area. A spacious driveway is visible, along with a white fence lining the property. Bright clouds can be seen against the blue sky, enhancing the outdoor setting.

Home in Strawberry Point

5 out of 5 average rating, 73 reviews

Old Mission Road House - A Home Away from Home

This is a newly built house with full kitchen. All dishes, pans and linens are supplied. There are 3 queen size bedrooms, 2 full bathrooms , washer and dryer. Flat screen TVs access to WIFI in the kitchen and in the loft area and also in each bedroom. Fully air conditioned. Front and back patio with chairs and table, grill and fire pit with wood supplied. Backbone State Park is three miles away. A great area for trout streams, hunting , hiking , golfing and snowmobling in the winter.

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Top guest favorite

A lush green landscape rises just beyond a calm river, with a small collection of buildings visible along the shore. The architecture varies, featuring both traditional and modern designs, under a sky filled with fluffy clouds.

Apartment in Clayton

4.94 out of 5 average rating, 176 reviews

Cozy Apartment Steps from the Mighty Mississippi

Disconnect from the daily grind and enjoy a getaway in this welcoming one bedroom apartment, steps away from the Mighty Mississippi. Located in Clayton, Iowa, Located within walking distance of two delicious restaurants and a boat launch., and only 1/2 hour from the Casino Queen, local wineries, Pikes Peak State Park, as well as the historic communities of Elkader, IA and Prairie Du Chien, WI. Need more space? I also offer a two bedroom apartment: www. airbnb. com/rooms/43979345

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Top guest favorite

Apartment in McGregor

5 out of 5 average rating, 29 reviews

Historic Charm in the Heart of McGregor, Iowa

2 Bedrooms • 1 Bathroom • Walk to the Mississippi River Welcome to your cozy getaway in the scenic river town of McGregor, Iowa! This beautifully updated two-bedroom, one-bath home combines small-town charm with modern comfort — perfect for couples, families, or friends looking to relax and explore. A bright, open living area with comfortable seating and local decor A fully equipped kitchen with everything you need to cook and dine in. Two spacious bedrooms with plush bedding.

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Guest favorite

A fire pit surrounded by green adirondack chairs is positioned on a gravel area, with a view of the Mississippi River in the background. Large trees provide shaded spots, and additional seating is visible near the water.

Tiny home in McGregor

4.81 out of 5 average rating, 140 reviews

The Cottage

A Quaint Cottage on the Mississippi River one mile north of Marquette, IA. One bedroom with additional sofa sleeper in the common area. Public boat landing, Casino and Winery all within one mile. Gas grill and fire pit on site. Effigy Mounds and Pikes Peak within 3 miles. Prairie du Chien just across the bridge. Great eating and shopping in nearby McGregor! Fun family getaway or great area for fishermen! Seasonal cottage books May thru Mid October.

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Top guest favorite

Home in Marquette

5 out of 5 average rating, 20 reviews

Pleasant Ridge Retreat

Charming 2-Bedroom Retreat Near the Mississippi River Just half a mile from the Mississippi River, this newly built 2-bedroom, 1-bathroom home offers the perfect escape for nature lovers, history buffs, or anyone looking to unwind in a tranquil setting. With an open-concept design, modern finishes, and plenty of natural light, this cozy retreat is ideal for summer getaways or fall stays to enjoy the vibrant autumn scenery.

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Superhost

A brick cottage is set among lush green grass, with a metal roof and partially covered by climbing vines. Decorative plants line the base of the house, and trees surround the property, adding to the natural landscape.

Cottage in Garnavillo

4.69 out of 5 average rating, 154 reviews

Valley Mills Miller's Cottage

Welcome to Valley Mills Miller's Cottage, where the beauty of "Mother Nature" surrounds you. Built six years after Iowa became a state in 1847, it is located in a remote picturesque valley containing Buck Creek Trout Stream. It is completely surrounded by wooded Bluffs, known as "Cold Slopes". With its two acre park like area, it is an ideal place for families to let their Kids/pets freedom to roam.

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Guest favorite

A rustic home's exterior is presented, showcasing a white façade with multiple large windows and a welcoming front porch. The porch features wooden steps, inviting entry. Surrounding greenery and a blue sky with clouds enhance the home’s charm, though no additional structures are visible.

Home in Prairie du Chien

4.9 out of 5 average rating, 40 reviews

Rustic 3Bed 2Bath Home near Downtown PDC

Bring family and friends to this rustic home located in Historic downtown Prairie Du Chien and 1 block from the river. Great location that puts you near all of the events this town has to offer. You are also 5 min from the casino!Whether you are visiting for the Mississippi River, downtown scene, hunting, fishing, or just to getaway for relaxation, this place will accommodate your interests!

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Guest favorite

Home in Guttenberg

5 out of 5 average rating, 20 reviews

Secluded Bardo Retreat w/ Hot Tub + View

Find Your Stillness | Omega Ridge Retreat on 6 Private Acres This one-of-a-kind property features a brand new Barndominium, perfect for couples’ getaways, family gatherings, small retreats, or anyone longing to unwind in nature without sacrificing comfort. This area is great for hiking hunting fishing, canoeing side-by-side riding & near the historic town of Guttenberg just 6 miles away.

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